NHR-8 and P-glycoproteins uncouple xenobiotic resistance from longevity in chemosensory mutants.

Longevity is often associated with stress resistance, but whether they are causally linked is incompletely understood. Here we investigate chemosensory-defective mutants that are long-lived and stress resistant. We find that mutants in the intraflagellar transport protein gene were significantly protected from tunicamycin-induced ER stress.