Publications by authors named "Klara Frydryskova"
Changing faces of stress: Impact of heat and arsenite treatment on the composition of stress granules.
Wiley Interdiscip Rev RNA
November 2020
Article Synopsis
- Different stressors, particularly arsenite and heat, lead to distinct SG properties, with differences noted in protein localization and dynamics that may relate to neurodegenerative diseases.
- The article suggests that SGs formed under heat stress could serve as a transitional model towards understanding the development of irreversible protein aggregates associated with conditions like Alzheimer's and ALS.
Alternative polyadenylation is an important and pervasive mechanism that generates heterogeneous 3'-termini of mRNA and is considered an important regulator of gene expression. We performed bioinformatics analyses of ESTs and the 3'-UTRs of the main transcript splice variants of the translational initiation factor eIF4E1 and its family members, eIF4E2 and eIF4E3. This systematic analysis led to the prediction of new polyadenylation signals.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the localization of different eIF4E protein isoforms, specifically eIF4E2 and eIF4E3, which have received less attention compared to the well-studied eIF4E1.
- eIF4E3_A was found to localize to stress granules during stress conditions like heat shock and arsenite exposure but does not localize to processing bodies, while eIF4E3_B does not localize to stress granules at all.
- The findings suggest that different eIF4E isoforms and their variants play unique roles in cellular stress responses by showing distinct patterns of localization and interactions with other translation initiation factors.