Publications by authors named "Klaas Jan Nauta"
Background: Valproic acid is one of the most widely prescribed drugs for the treatment of epilepsy and bipolar disorder. As only the unbound fraction of a medicinal product is pharmacologically active, in some strong protein-bound psychotropic drugs such as valproic acid and phenytoin, a rise in this fraction can lead to severe toxicity.
Case Description: A 65-year-old male with a type 1 bipolar disorder developed a number of neurological symptoms including sluggishness, muscle weakness, difficulty in walking and disorders of micturition after his mood stabiliser was changed to valproic acid.
Article Synopsis
- A 37-year-old homeless man from Albania experienced multiple fractures after jumping from a third-floor window due to his psychotic disorders.
- He was uninsured, refused hospital transfer due to paranoia, and ended up hospitalized for nearly 30 weeks, highlighting challenges like the combination of physical and mental health issues and lack of family support.
- The case underscores the importance of multidisciplinary evaluations in complex situations and encourages innovative solutions to balance patient care with cost-effectiveness in healthcare.
Aim: To evaluate the prevalence and the influence on survival of depressive symptoms in a European cohort of end-stage renal disease (ESRD) patients on renal replacement therapy (RRT).
Methods: In a prospective fashion, symptoms of depression were evaluated in ESRD patients on RRT using the depression subscore of the Hospital Anxiety and Depression Scale (HADS). Fatal and non-fatal clinical events were determined during a 1-year follow-up.