Influence of saline water and heavy rain on the fate of chlorinated ethenes in groundwater characterized by compound-specific isotope and microbial data.

Chlorinated ethenes are prevalent contaminants in industrial wastewater that detrimentally affect human health. As elevated tetrachloroethene (PCE) concentrations (18.0-18.

Changes in the potato rhizosphere microbiota richness and diversity occur in a growth stage-dependent manner.

Plant root and soil-associated microbiomes are influenced by niches, including bulk and rhizosphere soil. In this work, we collected bulk and rhizosphere soil samples at four potato developmental stages (leaf growth, flowering, tuber elongation and harvest) to identify whether rhizosphere microbiota are structured in a growth stage-dependent manner. The bacterial and fungal microbiota showed significant temporal differences in the rhizosphere and bulk soil.

Targeted dual biologic therapy for erythroderma of unknown etiology guided by high-parameter peripheral blood immunophenotyping.

Erythroderma is a severe and heterogeneous inflammatory skin condition with little guidance on the approach to management in cases of unknown etiology. To guide therapeutic selection, we sought to create an immunophenotyping platform able to identify aberrant cell populations and cytokines in subtypes of erythroderma. We performed high-parameter flow cytometry on peripheral blood mononuclear cells (PBMCs) and whole blood of a patient with refractory idiopathic erythroderma, erythrodermic patients with Sézary syndrome and pityriasis rubra pilaris, and healthy controls.

Perfluorocarbon-polyepinephrine core-shell nanoparticles as a near-infrared light activatable theranostic platform for bimodal imaging-guided photothermal/chemodynamic synergistic cancer therapy.

Activatable multifunctional nanoparticles present considerable advantages in cancer treatment by integrating both diagnostic and therapeutic functionalities into a single platform. These nanoparticles can be precisely engineered to selectively target cancer cells, thereby reducing the risk of damage to healthy tissues. Once localized at the target site, they can be activated by external stimuli such as light, pH changes, or specific enzymes, enabling precise control over the release of therapeutic agents or the initiation of therapeutic effects.

Biotissue Curriculum Translates to Performance in the Operating Room for Gastrojejunostomy and Hepaticojejunostomy in Robotic Pancreaticoduodenectomy.

Objective: Robotic simulation training curricula aim to aid surgeons in attaining robotic operating room proficiency, but the crossover success remains to be examined.

Design: A retrospective cohort study grading robotic biotissue training models and intraoperative anastomotic videos. The curriculum included deliberate practice of inanimate drills of a hepaticojejunostomy (HJ) and gastrojejunostomy (GJ).

Clinical and research applications of natural language processing for heart failure.

Natural language processing (NLP) is a burgeoning field of machine learning/artificial intelligence that focuses on the computational processing of human language. Researchers and clinicians are using NLP methods to advance the field of medicine in general and in heart failure (HF), in particular, by processing vast amounts of previously untapped semi-structured and unstructured textual data in electronic health records. NLP has several applications to clinical research, including dramatically improving processes for cohort assembly, disease phenotyping, and outcome ascertainment, among others.

3,6-Bis(methylthio)-9H-carbazole Based Self-Assembled Monolayer for Highly Efficient and Stable Inverted Perovskite Solar Cells.

The photovoltaic performance of inverted perovskite solar cells (PSCs) relies on effectively managing the interface between the hole extraction layer and the light-absorbing perovskite layer. In this study, we have synthesised (4-(3,6-bis(methylthio)-9H-carbazol-9-yl)butyl)phosphonic acid (MeS-4PACz), which forms a self-assembled monolayer (SAM) on the fluorine-doped tin oxide (FTO) electrode. The molecule's methylthio substituents generate a favourable interfacial dipole moment and interact with the perovskite layer.

Elevated C-reactive protein levels and cardiovascular risk in prurigo nodularis patients with sleep disturbance: a multi-center cohort study.

Patients with prurigo nodularis (PN) present with pruritus which may lead to sleep disturbances and systemic comorbidities. The objective of our study was to determine the risk of sleep disorders in PN and its association with systemic inflammation and adverse cardiovascular outcomes. We conducted a retrospective population-level cohort using a global health records database to analyze the development of sleep disorders, C-reactive protein (CRP) levels, and risk of cardiovascular disease and mortality in PN compared to controls.

Evaluating radionuclide mobility in groundwater recharge areas of fractured natural barrier systems using multiple isotopes and microbial indicators.

The distribution of uranium (U) concentrations, which reached up to 322 µg/L, was found to correlate with the pattern of fractures within the natural barrier system (NBS). Analysis of the vertical distribution of dissolved oxygen (DO), dissolved organic carbon (DOC), tritium (H), microbial communities, and HO and SO isotopes revealed insights into oxic water infiltration within the heterogeneous fractured system. Their distribution showed that the average infiltration depth at the KURT site is 200 m, while in external areas with a high frequency of fractures, oxic conditions extended down to 495 m.

Development of a novel strategy to reduce diagnostic errors in real-time polymerase chain reaction using probe-based techniques.

Real-time PCR assays are valuable tools for the rapid and accurate diagnosis of infectious diseases by identifying the nucleic acid sequences of pathogens. Here, we aimed to develop a recombinant plasmid-based standard for validating the sensitivity of different molecular diagnostic methods adopting the Jonstrup assay (J assay). Chimeric plasmid DNA (cpDNA) harboring various pathogen genes and the target site of the J assay was constructed.

Trajectory of health-related quality of life during and after hospitalisation due to worsening of heart failure.

Purpose: This study aimed to examine the trajectory in health-related quality of life (HRQoL) during and after hospitalisation for worsening of heart failure (HF) in Malaysia.

Methods: 200 patients with heart failure and reduced ejection fraction (HFrEF) admitted into two hospitals in Malaysia due to worsening of HF were surveyed using the EQ-5D-5 L questionnaire. The primary outcomes were utility values at admission, discharge and 1-month post-discharge (1MPD).

Thoron, radon and microbial community as supportive indicators of seismic activity in groundwater.

Earthquakes have a significant impact on groundwater environments as well as human life. However, identifying active and affected zones from seismic events using isotopic and microbial diversity indicators remains a challenging frontier. To validate the applicability of this coupled method for real-time analysis, we analyzed thoron (Rn), radon (Rn), microbial community compositions, and hydrochemistry in groundwater samples during the 2017 Pohang earthquake for the first time.

Pemetrexed-carboplatin salvage therapy in advanced thyroid cancers.

Background: The overall survival of patients with advanced thyroid cancers that have progressed following targeted therapies is limited, indicating a strong need for salvage treatments.

Methods: We retrospectively analyzed patients with refractory advanced thyroid cancer treated with pemetrexed-carboplatin (PC) at Mayo Clinic since 2019.

Results: Eleven patients, three with anaplastic thyroid cancer (ATC), seven with differentiated or poorly differentiated thyroid cancer (DTC), and one with oncocytic carcinoma of the thyroid, were treated with novel salvage PC.

Acceptability and quality of the 'Grog Survey App' brief intervention: Helping Aboriginal Australians reflect on their drinking using a digital health tool.

Introduction: The Grog Survey App is a validated, visual and interactive self-administered application for tablet computers that is designed to help Aboriginal Australians describe their alcohol consumption. Each person who completes the App also receives a brief intervention with feedback tailored to their survey responses. We aimed to qualitatively assess the acceptability and perceived quality of the Grog App's brief intervention, among higher risk consumers and health providers at an Aboriginal residential rehabilitation centre.

Maleic anhydride derivatives as catalysts for -oxidation of pyridine using hydrogen peroxide.

Maleic anhydride derivatives were evaluated as catalysts in -oxidation of various pyridine substrates using hydrogen peroxide (HO). Depending on the electronic properties of the pyridine substrates, pyridines with electron-donating groups reacted well with 2,3-dimethylmaleic anhydride (DMMA). In contrast, 1-cyclohexene-1, 2-dicarboxylic anhydride (CHMA) was most effective for electron-deficient pyridines.

Evaluation of intensive remediation using simulation-optimization modeling based on long-term monitoring at a DNAPL contaminated site.

Simulation-optimization modeling is extensively used to identify optimal remediation designs. However, verifying these optimal solutions often remains unclear. In this study, we determine optimal groundwater remediation strategies using simulation-optimization modeling and assess the effectiveness of previous remediation efforts by validating optimized results through 14 years of long-term monitoring of trichloroethylene (TCE) contamination.

How I Do It: Using ChatGPT to Create Clinical Scenarios for Surgical Learning and Oral Boards Preparation.

Objective: To evaluate the use of the large language model ChatGPT to simulate an oral surgical boards examination environment.

Design: ChatGPT was asked to create oral surgical boards questions based on a series of clinical scenarios.

Results: ChatGPT created clinically relevant oral board-type questions.

Design and Pilot Implementation of an ECHO Module on Hepatitis C Virus Infection During Pregnancy.

We developed a Project ECHO® module to offer prenatal providers training on engaging in shared decision-making about hepatitis C virus (HCV) treatment during pregnancy. In this pilot program, the ECHO module addressing HCV during pregnancy and the potential benefits of treatment was associated with increases in self-efficacy scores among participants.