A First Clinical Trial on Botulinum Toxin-A for Chronic Muscle-Related Pain in Cerebral Palsy.

To test if botulinum toxin-A (BoNT-A) is effective in reducing chronic muscle-related pain in adults with spastic cerebral palsy (CP), as compared to placebo. A single-center, double-blind, parallel, randomized placebo-controlled trial. The design included an interim analysis to allow for confirmatory analysis, as well as pilot study outcomes.

Sensitivity of the NeuroFlexor method to measure change in spasticity after treatment with botulinum toxin A in wrist and finger muscles.

Objective: The NeuroFlexor objectively quantifies the neural, elastic and viscous components of passive movement resistance in wrist and finger flexor muscles. In this study we investigated the sensitivity of the NeuroFlexor to changes in spasticity induced by treatment with botulinum toxin type A (BoNT-A).

Design: Prospective observational design.

Focal spasticity therapy with botulinum toxin: effects on function, activities of daily living and pain in 100 adult patients.

Objective: Analysis of the effects of a comprehensive focal spasticity program in adult patients.

Design: Retrospective study of an out-patient cohort.

Patients: One hundred patients were enrolled in the study (54 men and 46 women, mean age 41 years (SD 14).