Publications by authors named "Kiyoshiro Nagamatsu"
Article Synopsis
- Mechanical thrombectomy (MT) effectively treats large vessel occlusions in cerebral infarction patients, but use of iodine contrast agents can lower thyroid hormone levels due to the Wolff-Chaikoff effect.
- A study involving 31 patients found significant decreases in thyroid stimulating hormone (TSH) and free T3 (FT3) levels 24 hours post-MT.
- The study also revealed that the reduction in FT3 was correlated with the amount of iodine contrast agent used, indicating potential impacts on thyroid hormone levels after the procedure.
Objective: Iterative reconstruction (IR) is a noise reduction method that facilitates the synthesis of maximum intensity projection (MIP) from a larger number of slices while maintaining resolution. The present study aimed to analyze whether CT evaluation using IR and MIP is ideal for thrombus evaluation of large vessel occlusions in patients with acute ischemic stroke.
Methods: Three types of images for each patient were reconstructed and categorized into three groups: the "conventional group," evaluated using 0.
Article Synopsis
- - The study investigates the impact of intracranial branch atheromatous disease on motor function due to infarctions in the lenticulostriate arteries (LSA), focusing on distinct patterns of lesions observable via MRI.
- - Researchers retrospectively analyzed 1,840 patients from a Japanese hospital, classifying them into two groups based on the location and pattern of infarcts: a single group with a single lesion and a scattered group with multiple distal lesions.
- - Findings reveal that patients with scattered infarcts experienced significantly worse progress post-hospitalization and were identified as more likely to have increased disease severity, emphasizing that scattered lesions are a predictor of poorer outcomes.
Article Synopsis
- - The main neurological issue in spontaneous intracranial hypotension (SIH) is paresis of the abducens nerve, but the exact cause is not fully understood.
- - Current understanding suggests that the downward movement of brain contents pulls on cranial nerves, leading to this nerve weakness.
- - Recent MRI findings show that the cavernous sinuses are thicker due to venous swelling from cerebrospinal fluid leakage, which pushes on the abducens nerve, resulting in paresis.
A 52-year-old man experienced sudden-onset global amnesia and left limb ataxia. An embolism of the right anterior cerebral artery resulted in anterior cingulate cortex (ACC) infarction, and working memory dysfunction persisted. The ACC, prefrontal cortex, and bilateral superior parietal lobule exhibited decreased activity on single-photon emission computed tomography (SPECT).
View Article and Find Full Text PDFFabry disease is an important underlying disease in young cryptogenic stroke patients. However, little is known regarding the frequency of Fabry disease in the general stroke population, especially in elderly patients. A total of 588 stroke patients (61.
View Article and Find Full Text PDFTransthyretin (TTR) is a homotetrameric protein that must misfold in order to form amyloid fibrils. Misfolding includes rate limiting tetramer dissociation, followed by fast tertiary structural changes of the monomer that enable aggregation. Hereditary ATTR amyloidosis is an autosomal dominant genetic disorder with systemic deposition of amyloid fibrils induced by TTR gene mutation.
View Article and Find Full Text PDFA Japanese family with a novel nonsense mutation in the TITF-1 gene (p.Y98X) is described. The proband showed severe generalized chorea, delayed motor development, subnormal intelligence, congenital hypothyroidism, bronchial asthma, and a history of pulmonary infection, all of which are characteristic features of Brain-Thyroid-Lung syndrome.
View Article and Find Full Text PDFFabry's disease is an X-linked lysosomal storage disorder resulting from alpha-galactosidase A deficiency. Although ischemic stroke is recognized as an important manifestation of Fabry's disease, hemorrhagic stroke is considered to be rare. Here, we report our recent clinical experience with three hemizygous male patients with Fabry's disease who developed cerebral hemorrhage.
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