The effects of a selective cyclooxygenase-2 inhibitor on small bowel ischemia-reperfusion injury.

Background/aims: The purpose of this study was to investigate the effects of a selective COX-2 inhibitor, FK3311, on warm ischemia-reperfusion injury of the canine small intestine.

Methodology: Ten adult mongrel dogs were used. FK (1 mg/kg) was administered intravenously 15 minutes prior to ischemia and 15 minutes prior to reperfusion in the FK group (n = 5), and only an inert vehicle was injected in the control group (n = 5).

The effect of FR167653 in a canine total hepatic vascular exclusion model.

Background/aims: Though liver grafts from non-heart-beating donors are now attracting much attention, these grafts inevitably suffer from severe warm ischemia. The aim of this study was to evaluate the effect of TNF-alpha and IL-1 suppression on warm ischemia-reperfusion injury in a canine total hepatic vascular exclusion model.

Methodology: Warm ischemia was induced by 1-h total hepatic vascular exclusion with active splenofemuro-juglar bypass.