Publications by authors named "Kiyonori Kuriki"
Aim: We examined the association between dairy intake and all-cause, cancer, and cardiovascular disease mortality in a cohort of the general population followed up for 12 years across Japan.
Methods: We conducted a longitudinal cohort study of 79,715 participants from the Japan Multi-Institutional Collaborative Cohort study (57.2% women, mean age 54.
The prospective cohort study in a large Japanese population suggested that metabolic phenotypes are important risk factors for total and some site-specific cancers in Japanese adults. Moreover, the risk of each site-specific cancer may differ according to metabolic phenotypes.
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- The study explored the relationship between polygenic risk scores (PRS) for blood pressure and mortality due to cardiovascular disease (CVD) and all causes, particularly considering environmental lifestyle factors.
- It analyzed data from 9,296 participants over a median follow-up of 12.6 years, finding that higher PRS groups had significantly increased risks of CVD mortality compared to medium PRS groups.
- The findings suggest that combining genetic risk factors with lifestyle information could help identify individuals who might benefit from targeted lifestyle interventions, despite the PRS having limited ability to independently predict outcomes.
Article Synopsis
- - This study investigated the link between small fish consumption and mortality rates, focusing on a cohort of 80,802 participants in Japan aged 35-69.
- - Results showed that higher intake of small fish significantly lowered the risk of all-cause and cancer-related deaths in females, while no notable relationship was found for males.
- - The findings suggest that incorporating small fish into the diet may be beneficial for reducing mortality risks, particularly for women.
Article Synopsis
- This study addresses the genetic factors affecting kidney function in East Asians, particularly the Japanese, highlighting the need for more extensive GWAS with larger sample sizes due to limited previous research.* -
- Utilizing data from around 200,000 Japanese participants, the authors conducted a meta-analysis that revealed 110 loci linked to estimated glomerular filtration rate (eGFR) and 112 loci associated with serum creatinine (SCr).* -
- The findings include a novel variant (CD36 rs146148222) and suggest that understanding these genetic associations can lead to personalized strategies for preventing kidney diseases in the future.*
Article Synopsis
- A study investigated the genetic factors influencing alcohol consumption in 175,672 Japanese individuals, focusing on a specific genetic variant (rs671) associated with drinking behavior.
- The analysis found significant genetic interactions, identifying three key genetic locations in individuals with one variant (wild-type homozygotes) and six in those with two variants (heterozygotes), with some linked to esophageal cancer risk.
- The research highlights how genetic makeup can shape alcohol consumption patterns and potentially increase the risk of alcohol-related diseases in different ancestral groups.
This study aimed to investigate the association between daily sedentary time and the risk of breast cancer (BC) in a large Japanese population. The participants were 36,023 women aged 35-69 years from the Japan Multi-Institutional Collaborative Cohort Study. Cox proportional hazards analysis was used to estimate adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for BC incidence in relation to time spent sedentarily (categorical variables: <7 and ≥7 hours/day [h/d]).
View Article and Find Full Text PDFBackground: Improving diets requires an awareness of the need to limit foods for which excessive consumption is a health problem. Since there are limited reports on the link between this awareness and mortality risk, we examined the association between awareness of limiting food intake (energy, fat, and sweets) and all-cause mortality in a Japanese cohort study.
Methods: Participants comprised 58,772 residents (27,294 men; 31,478 women) aged 35-69 years who completed baseline surveys of the Japan Multi-Institutional Collaborative Cohort Study from 2004 to 2014.
Article Synopsis
- The GWAS focused on identifying genetic loci linked to folate metabolites such as homocysteine, folic acid, and vitamin B levels in a Japanese cohort.
- The study analyzed data from 2,263 participants in the J-MICC Study and replicated findings in 573 participants from the Yakumo Study, highlighting significant loci on chromosomes 1, 11, and 16.
- Results indicated notable gene-environment interactions, particularly involving the MTHFR gene and factors like alcohol consumption and physical activity, suggesting implications for personalized cardiovascular disease prevention.
Background: Previous cohort studies have yielded contradictory findings regarding the associations of dietary carbohydrate and fat intakes with risks of mortality.
Objectives: We examined long-term associations of carbohydrate and fat intakes with mortality.
Methods: In this cohort study, 34,893 men and 46,440 women aged 35-69 y (mean body mass index of 23.
The association between kidney function and cancer incidence is inconsistent among previous reports, and data on the Japanese population are lacking. It is unknown whether kidney function modifies the cancer risk of other factors. We aimed to evaluate the association of estimated glomerular filtration rate (eGFR) with cancer incidence and mortality in 55 242 participants (median age, 57 years; 55% women) from the Japan Multi-Institutional Collaborative Cohort Study.
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- The study investigates genetic factors influencing hemoglobin A1c (HbA1c) and blood glucose levels in a non-diabetic Japanese population, using a two-phase genome-wide association study (GWAS).
- The research involved 4911 initial participants and replicated findings with a larger sample size from the Tohoku Medical Megabank project, adjusting for variables such as age, sex, BMI, and smoking.
- Results showed a specific genetic variant (rs2299620) linked to HbA1c levels, with its impact varying according to BMI categories, whereas no variants for blood glucose levels were successfully replicated.
This four-season observational study aimed to examine the mediating role of the gut microbiota in the associations between green tea and catechin intakes and glucose metabolism in individuals without type 2 diabetes mellitus (T2DM). In each of the 4 seasons, 85 individuals without T2DM (56 male [65.9%]; mean [standard deviation] age: 43.
View Article and Find Full Text PDFThe association between vitamin D and total and colorectal cancer risk was inconsistent in observational studies. We conducted Mendelian randomization approach in which the effect of confounding might be reduced. 110 single nucleotide polymorphisms (SNPs) associated with 25-hydroxyvitamin D concentrations were systematically selected according to the "GWAS Catalog" from all ethnic populations.
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- - The study examines how gene-lifestyle interactions influence body mass index (BMI) and emphasizes the need for personalized nutrition in obesity treatment strategies, as current evidence is limited.
- - Using data from over 12,000 participants, researchers found a significant correlation (r = 0.13) between a multi-locus genetic risk score (GRS) and BMI, highlighting the impact of genetic factors on obesity.
- - Results showed interactions between GRS and certain dietary intakes, such as saturated fatty acids and n-3 polyunsaturated fatty acids, suggesting that personalized dietary recommendations based on genetic predisposition could improve obesity prevention and treatment.
Aims: The association between dietary patterns and serum low density lipoprotein (LDL) cholesterol would be changing in recent dietary habits in Japan. We investigated the relationship between dietary patterns and serum LDL cholesterol in a large general population.
Methods: From the baseline survey of Japan Multi-Institutional Collaborative Cohort Study between 2005 and 2013, 27,237 participants (13,994 were women) aged 35-69 years were cross-sectionally analyzed.
Background And Aims: To date, the relationship between coffee consumption and metabolic phenotypes has hardly been investigated and remains controversial. Therefore, the aim of this cross-sectional study is to examine the associations between coffee consumption and metabolic phenotypes in a Japanese population.
Methods And Results: We analyzed the data of 26,363 subjects (aged 35-69 years) in the baseline survey of the Japan Multi-Institutional Collaborative Cohort Study.
Background: Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated.
Methods: We conducted individual-level Mendelian randomization (MR) analyses targeting 14,083 participants in the Japan Multi-Institutional Collaborative Cohort Study and two-sample MR analyses using summary statistics based on genome-wide association study data from 173,430 Japanese. Using 83 body mass index (BMI)-related loci, genetic risk scores (GRS) for BMI were calculated, and the effects of BMI on cardiometabolic traits were examined for individual-level MR analyses using the two-stage least squares estimator method.
Objective: Findings on the increased mortality risk in individuals with insomnia are inconsistent across studies. Rather than improving insomnia by sleep control, hypnotic use may be one factor in the increased risk of death; however, the effects of hypnotics on mortality remains unclear. This study aimed to examine the association between all-cause mortality and hypnotic use in a large sample, while adjusting for the effects of comorbidities.
View Article and Find Full Text PDFObjectives: Previous studies using objective parameters have shown that irregular sleep is associated with the disease incidence, progression, or mortality. This study aimed to determine the association between subjective sleep duration and sleep regularity, with mortality in a large population.
Methods: Participants were from the Japan Multi-Institutional Collaborative Cohort study.
Article Synopsis
- Genetic factors influence how individuals experience pain, prompting researchers to conduct a genome-wide association study (GWAS) focused on patients with cancer pain and the general population.
- The study combined two cohorts: an exploratory group assessed using pain intensity ratings and opioid dosages, and a confirmatory group that evaluated habitual use of nonsteroidal anti-inflammatory drugs.
- A novel single-nucleotide polymorphism (SNP) associated with pain was identified on chromosome 7, linked to the gene for pleiotrophin, which showed significant correlations with analgesic use, although its minor allele affected pain in the opposite way than expected.
Unlabelled: The associations between blood lipids, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides, and low-density lipoprotein cholesterol (LDL-C), and colorectal cancer risk are controversial. We evaluated potential causal relationships between blood lipids and colorectal cancer risk. Using the baseline data from the Japanese Consortium of Genetic Epidemiology studies, we estimated the single-nucleotide polymorphism (SNP)-exposure associations (n = 34,546 for TC, n = 50,290 for HDL-C, n = 51,307 for triglycerides, and n = 30,305 for LDL-C).
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- - This study investigated the link between Oral Health Indices (OHIs), which include self-care habits and hygiene practices, and the risk of obesity among Japanese adults aged 35-79.
- - Data was collected from 6046 participants (3494 men and 2552 women), measuring their body mass index (BMI) and responses to 15 OHI-related questions.
- - Results indicated a clear association, with higher obesity risk linked to poor oral health practices, particularly in tooth brushing and self-care habits, emphasizing the importance of maintaining good oral health to potentially reduce obesity risk.
Purpose: The association between metabolic syndrome (MetS) and the risk of death from cancer is still a controversial issue. The purpose of this study was to examine the associations of MetS and metabolically unhealthy obesity (MUHO) with cancer mortality in a Japanese population.
Methods: We used data from the Japan Multi-Institutional Collaborative Cohort Study.
Background: Although many polygenic risk scores (PRS) for cardiovascular traits have been developed in European populations, it is an urgent task to construct a PRS and to evaluate its ability in non-European populations. We developed a genome-wide PRS for blood pressure in a Japanese population and examined the associations between this PRS and hypertension prevalence.
Methods: We performed a cross-sectional study in 11 252 Japanese individuals who participated in the J-MICC (Japan Multi-Institutional Collaborative Cohort) study.