Publications by authors named "Kiyomi Imamura"
Article Synopsis
- The study investigates cell-cell interactions in colorectal cancer (CRC) to understand how adenomas progress to sporadic CRC, aiming to improve patient survival rates.
- By using spatial transcriptomics on early and advanced CRC cases, the researchers identified key interactions between cancer cells and regulatory T cells (Tregs) that may lead to immune suppression in the tumor microenvironment.
- Findings highlight midkine (MDK) as a critical signaling molecule involved in these interactions and indicate that higher MDK/SDC4 levels are linked to poorer survival outcomes in CRC patients, suggesting a potential target for early diagnosis and treatment.
Article Synopsis
- Epigenomes play a crucial role in correcting abnormal gene expressions in cancer, and targeting histone H3K27me3 is effective for new drug therapies, although the mechanisms are not fully understood.
- Valemetostat, an EZH1-EZH2 dual inhibitor, has shown promise in clinical trials for aggressive lymphomas by reducing tumor size and providing long-lasting responses even in genetically diverse cancer cases.
- However, resistance develops over time due to mutations that restore condensed chromatin states, leading to increased H3K27me3 expression and highlighting the need for innovative epigenetic therapies to overcome such challenges in cancer treatment.
Article Synopsis
- * Key genes related to NMJ formation, including Dok7, Chrna1, and Chrnd, were found to be expressed in myonuclei at a critical stage of embryonic development (E18.5), with around 10.7% of myonuclei expressing these genes alongside regulators like Amotl2 and Ptprk.
- * Distinct roles were identified for various β-catenin regulators, where Amotl2 and Ptprk were crucial for NMJ structural organization, while Fam53b
Article Synopsis
- The study explores how cellular interactions in the tumor microenvironment affect treatment strategies for colorectal cancer (CRC), focusing on the invasion front of tumors.
- By combining spatial transcriptomics and a single-cell transcriptomic atlas, researchers analyze CRC tissues to better understand cell-to-cell communication in this critical area.
- The findings reveal that CRC cells at the invasion front can influence macrophages and enhance both their own growth and invasiveness while simultaneously evading anti-tumor immunity.
