Nerve sheath myxoma (neurothekeoma) arising in the oral cavity: histological and immunohistochemical features of 3 cases.

This report describes the histological and immunohistochemical characteristics of 3 cases of nerve sheath myxoma (NSM)/neurothekeoma arising in the oral cavity. Histopathologically, 3 distinct variants were observed based on the amount of myxoid matrix: classic/hypocellular, cellular, and mixed types. Immunohistochemically, all types expressed strong immunoreactivity to S-100 protein (3/3), NSE (neuron-specific enolase) (3/3), and NGFR (nerve growth factor receptor) (3/3), whereas all cases were negative for SMA (smooth muscle actin) and FVIII.

A male infant case of lipofibromatosis in the submental region exhibited the expression of the connective tissue growth factor.

Purpose: We encountered a case of lipofibromatosis in a 21-month-old male patient and examined its histopathologic properties.

Methods: We examined morphological aspects of the tumor and immunohistochemical patterns.

Results: Tumor proliferation was infiltrative, which did not show apparent encapsulation.