Publications by authors named "Kiyohumi Furusawa"
J Periodontal Res
February 2009
Article Synopsis
- - This study investigates how human gingival fibroblasts (HGFs) respond to lipopolysaccharide (LPS), a component associated with inflammation in periodontal disease, specifically looking at their ability to maintain production of inflammatory cytokines like IL-6 and IL-8.
- - Researchers found that HGFs do not develop LPS tolerance, meaning they continue to produce these inflammatory cytokines after being exposed to LPS, unlike monocytes and macrophages that can exhibit tolerance.
- - The findings imply that HGFs may play a significant role in sustaining inflammation in periodontal disease by persisting in cytokine production without exhibiting the negative regulatory mechanisms typically seen in other immune cells.
