Publications by authors named "Kiyohiko Takagishi"

In lactating animals, the food consumption increases several-fold for milk supply to the pups. The present study was conducted to clarify the relationship between the hyperphagia during lactation and hypothalamic leptin receptor (Ob-Rb) mRNA expression, cerebrospinal fluid (CSF) and circulating leptin and glucose levels. Food intakes significantly higher in lactation than in non-lactation at all time points (3 points: light phase, 4 points: dark phase) of the day.

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DEAD-box polypeptide 4 (DDX4) is an evolutionally conserved ATP-dependent RNA helicase that is exclusively expressed in germ cell lineage. Although DDX4 is believed to reside and function in the cytoplasm, recent studies in mice and humans suggest that its epitope is expressed on the cell surface of a small subpopulation in the ovary, putative oogonial stem cells. No study has examined whether such cell-surface DDX4(+) cells exist in the testes of any species.

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Article Synopsis
  • Doxorubicin, an anticancer drug, negatively affects calcium (Ca2+) functions in heart cells, contributing to its cardiotoxicity.
  • Mitoxantrone, another anticancer agent, shows less cardiotoxicity and enhances Ca2+ release in heart muscle experiments performed on guinea pigs.
  • Research findings indicate that mitoxantrone improves sarcoplasmic reticulum functions, unlike doxorubicin, which may explain its lower risk of heart-related side effects.
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