Decoding Drug Discovery: Exploring A-to-Z In Silico Methods for Beginners.

The drug development process is a critical challenge in the pharmaceutical industry due to its time-consuming nature and the need to discover new drug potentials to address various ailments. The initial step in drug development, drug target identification, often consumes considerable time. While valid, traditional methods such as in vivo and in vitro approaches are limited in their ability to analyze vast amounts of data efficiently, leading to wasteful outcomes.

An Uncommon Coronary Anomaly: A Single Right Coronary Artery With a Conus Branch Supplying the Left Anterior Descending Artery.

Coronary artery anomalies (CAAs) are usually asymptomatic and have a good prognosis. Single coronary artery anomaly (SCA) is a very rare CAA. Its true incidence is unknown.

Enhanced Hydrazine Electrooxidation Activities on Novel Benzofused Tricyclic Heterocyclic Derivatives.

In this study, some benzofused tricyclic heterocyclic derivatives have been tested as possible new catalysts for anode hydrazine electrooxidation in a direct hydrazine fuel cell (DHFC). Electrochemical studies were carried out in solution media containing 1 M KOH and 1 M KOH + 0.5 M NH using electrochemical techniques such as cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and chronoamperometry (CA).

Higher C-Reactive Protein to Albumin Ratio Portends Long-Term Mortality in Patients with Chronic Heart Failure and Reduced Ejection Fraction.

: In this study, we aimed to investigate the prognostic value of the C-reactive protein to albumin ratio (CAR) for all-cause mortality in patients with chronic heart failure with reduced ejection fraction (HFrEF). : In total, 404 chronic HFrEF patients were included in this observational and retrospective study. The CAR value of each patient included in this analysis was calculated.

Percutaneous interventions of coronary artery fistulas: a single-center experience.

Introduction: Coronary artery fistula (CAF) is a congenital communication between the coronary artery and other vascular structures or cardiac chambers. Percutaneous CAF closure is an emerging alternative to surgery, but long-term outcome data are limited.

Aim: To review our center's experience with percutaneous CAF closure methods.

The Relationship Between Echocardiographic Calcification Score and Grade of Knee Osteoarthritis.

Background and objective It has been suggested that knee osteoarthritis (KOA) is associated with the development of calcification and an increased risk of cardiovascular (CV) disease, while the contribution of KOA grade is not clearly known enough. This study aimed to investigate the relationship between the grade of KOA, the echocardiographic calcification score (echo-CCS), and CV risk assessment. Methods This cross-sectional study involved 204 patients diagnosed with KOA and classified according to the Kellgren-Lawrence staging criteria.

How Efficient Is ChatGPT in Accessing Accurate and Quality Health-Related Information?

Background and objective The field of artificial intelligence (AI) is advancing at a rapid pace, impacting all aspects of human life. Chat Generative Pre-trained Transformer (ChatGPT), which represents one of AI's most recent and remarkable achievements, has garnered significant attention and popularity in the academic community. ChatGPT, a language model-based chatbot developed by OpenAI, responds quickly and provides answers to the questions put to it.

Predictive Performance of Triglyceride-Glucose Index on Asymptomatic Multiple Organ Damage in Patients with Newly Diagnosed Hypertension.

Background: Insulin resistance (IR) contributes to the development of hypertension and mediated organ damage (HMOD) through various mechanisms.

Objectives: The objective of the study was to assess the diagnostic performance of the triglyceride-glucose (TyG) index, a surrogate marker of IR, in predicting the presence and severity of HMOD in newly diagnosed untreated hypertensive patients from an academic training and research hospital

Methods: The study included 438 patients with newly diagnosed, untreated hypertension. The control group comprised normotensive individuals matched on a 1:1 ratio based on age, gender, body mass index, and smoking using the nearest neighbor method.

Efficacy of autologous stem cell therapy in femoral head avascular necrosis: a comparative study.

Objective: Avascular necrosis of the femoral head is a disease usually seen in middle-aged individuals. Although many aetiological factors have been blamed, there are still aetiological factors that have not been fully elucidated. Although treatment options show a wide range, early and appropriate treatment is of great importance to preserve the hip joint.

Unlocking Promising Therapies: Drug-Eluting Stents in Medically Refractory Angina Patients With Myocardial Bridging.

Myocardial bridging (MB) is a congenital variation in which a coronary artery segment tunnels through the myocardium instead of following its usual epicardial route. Although MB is usually diagnosed incidentally and has a good long-term prognosis, it can lead to complications such as angina, myocardial infarction, arrhythmias, and sudden death. This study aimed to evaluate the outcomes of drug-eluting stent (DES) implantation in patients with MB and medically refractory angina.

Effect of Glenohumeral Joint Bone Morphology on Anterior Shoulder Instability: A Case-Control Study.

Purpose: Glenohumeral joint compatibility and bone morphology are among the most critical factors in shoulder stabilization. Our study investigated the effect of the bone morphological structure of the shoulder joint on anterior shoulder dislocation.

Methods: In our study, people with a history of shoulder dislocation were selected as the patient group.

Relationship between systemic inflammation indices and time of symptom onset in cardiac remodeling after first ST-segment elevation myocardial infarction.

Background: Circadian variations play a pivotal role in both leukocyte trafficking and inflammatory response. This may affect the course of cardiac healing after myocardial infarction (MI).

Aims: The present study investigated the relationship between the systemic immune inflammation (SII) index and the systemic inflammation response index (SIRI), two new inflammation indices integrating white blood cell subsets and platelets, and the time of onset of symptoms in left ventricular adverse remodeling (LVAR) after ST-segment elevation MI (STEMI).

Lumbosacral fusion increases the risk of hip osteoarthritis.

Objective: There may be biomechanical changes in the adjacent hip joint after lumbosacral fusion. The literature has limited information on how these biomechanical changes may result in hip joint space.

Material: METHOD: Our retrospective study examined hip joint space narrowing in patients who underwent lumbosacral fusion between 2020 and 2022.

Is blood group a risk factor in lateral epicondylitis?

Objective: Lateral epicondylitis is a common disorder in the community. Identification of risk factors plays an important role in the prevention and treatment of the disease. In our study, the relationship between risk factors in lateral epicondylitis and blood group, which has not been mentioned before in the literature, will be examined.

Evaluation of depression, anxiety symptoms, emotion regulation difficulties, and self-esteem in children and adolescents with obesity.

Objective: Pediatric obesity negatively affects many areas of mental health, especially anxiety and depression. This study aimed to investigate the effects of obesity on anxiety, depression, self-esteem, and emotion regulation in children and adolescents.

Methods: Our study included 50 children and adolescents aged 11-17 years with a diagnosis of obesity and 48 control participants.

Comparison of the Clinical Results of Platelet-Rich Plasma, Steroid and Autologous Blood Injections in the Treatment of Chronic Lateral Epicondylitis.

Background: The aim of our study is to compare the efficacy of PRP, steroids, and autologous blood injection in patients with chronic lateral epicondylitis.

Method: A total of 120 patients comprised our study. Three groups of 40 patients each received only one of the following: PRP, steroids, or autologous blood injections.

How high is the quality of the videos about children's elbow fractures on Youtube?

Objective: Pediatric elbow fractures are children's most common fractures. People use the internet to get information about their illnesses and also to search for treatment options. Videos uploaded to Youtube do not go through the review process.

Screening the possible anti-cancer constituents of Hibiscus rosa-sinensis flower to address mammalian target of rapamycin: an in silico molecular docking, HYDE scoring, dynamic studies, and pharmacokinetic prediction.

One of the most common malignancies diagnosed and the leading cause of death for cancer-stricken women globally is breast cancer. The molecular subtype affects therapy options because it is a complex disorder with multiple subtypes. By concentrating on receptor activation, mTOR (mammalian target of rapamycin) can be employed as a therapeutic target.

Evaluation of left ventricle systolic functions with 2D strain echocardiography after transcatheter aortic valve replacement in patients with severe aortic stenosis.

Objective: There is deterioration in global left ventricular (LV) longitudinal function in patients with severe aortic valve stenosis, and the decrease in LV global longitudinal strain (GLS) is associated with worsening prognosis. The aim of the study is to examine LV mechanical changes with LV strain imaging in addition to routine examination in patients who underwent transcatheter aortic valve replacement (TAVR).

Methods: Fifty patients who had been scheduled for the TAVR procedure between 2016 and 2018 were enrolled.

Discovery of potential mTOR inhibitors from Cichorium intybus to find new candidate drugs targeting the pathological protein related to the breast cancer: an integrated computational approach.

Breast cancer is the most common malignancy among women. It is a complex condition with many subtypes based on the hormone receptor. The mammalian target of the rapamycin (mTOR) pathway regulates cell survival, metabolism, growth, and protein synthesis in response to upstream signals in both normal physiological and pathological situations, primarily in cancer.