Correlating cobalt redox couples to photovoltage in the dye-sensitized solar cell.

We report a series of structurally analogous cobalt mediators related to [Co-bpy]Z (bpy = 2,2'-bipyrimidine, Z = 2+ or 3+) to demonstrate a linear relationship between the redox potential of the Co(iii/ii)-based redox couple (Emed) and open-circuit voltage (VOC) of the DSSC. The Emed values vary from 0.42 to 1.

High-Voltage Dye-Sensitized Solar Cells Mediated by [Co(2,2'-bipyrimidine)].

The cobalt complex [Co(2,2'-bipyrimidine)](PF) (Co-bpm) was tested as a redox mediator in the dye-sensitized solar cell. The measured photovoltages for the cells were in excess of 1 V, which is approximately 3-fold greater than that measured for devices where [Co(2,2'-bipyridine)](PF) (Co-bpy) was used as the redox mediator under the same experimental conditions. The root cause of this voltage enhancement is the Co/Co redox potential for Co-bpm being positively shifted by 0.

"Click" synthesis of small-molecule inhibitors targeting caspases.

A panel of 198 P4-diversified aldehyde (reversible) and vinyl sulfone (irreversible) inhibitors is successfully synthesized via an efficient "click chemistry" platform and directly screened against caspase-3 and -7 for inhibition.

Inhibitor fingerprinting of matrix metalloproteases using a combinatorial peptide hydroxamate library.

We report the inhibitor fingerprints of seven matrix metalloproteases, representing all five established families of this important class of enzymes, against a highly diversified small-molecule library. A total of 1400 peptide hydroxamates were individually prepared by systematically permuting both natural and unnatural amino acids across the P1', P2', and P3' positions, thereby generating an inhibitor library with three-pronged structural diversity. High-throughput screenings were efficiently conducted in microtiter plate format, providing a rapid and quantitative determination of inhibitor potency across the panel of enzymes.