Publications by authors named "Kittiporn Phanvijhitsiri"
Glutamine is considered a nonessential amino acid; however, it becomes conditionally essential during critical illness when consumption exceeds production. Glutamine may modulate the heat shock/stress response, an important adaptive cellular response for survival. Glutamine increases heat induction of heat shock protein (Hsp) 25 in both intestinal epithelial cells (IEC-18) and mesenchymal NIH/3T3 cells, an effect that is neither glucose nor serum dependent.
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- The study investigates how the intestinal apical transporter hPepT1 facilitates the uptake of muramyl dipeptide (MDP) in intestinal epithelial cells, leading to the activation of the NOD2/CARD15 gene and downstream signaling pathways like NF-kappaB.
- Experiments with Caco2/bbe cell monolayers showed that increases in hPepT1 expression enhanced MDP uptake and NF-kappaB activation, while silencing hPepT1 reduced these effects, suggesting a direct relationship between hPepT1 and MDP signaling.
- Findings reveal that MDP uptake by hPepT1 promotes the production of inflammatory markers such as interleukin-8, indicating its
Circadian clocks are thought to enhance the fitness of organisms by improving their ability to adapt to extrinsic influences, specifically daily changes in environmental factors such as light, temperature, and humidity. Some investigators have proposed that circadian clocks provide an additional "intrinsic adaptive value," that is, the circadian clock that regulates the timing of internal events has evolved to be such an integral part of the temporal regulation that it is useful in all conditions, even in constant environments. There have been practically no rigorous tests of either of these propositions.
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