Polyprenylated Benzoylphloroglucinols Isolated from Species and Their Cytotoxic Effects on Cancer Cell Lines.

Polyprenylated benzoylphloroglucinols (PPBPs) make up a group of complex natural products with anticancer potentials that are mainly distributed in plants. As part of our intensive exploration on new bioactive substances from this genus, we report two undescribed PPBPs, picrorhizones I () and J (), along with four known analogues (-) from the stem bark of and . The new structures were elucidated on the basis of spectroscopic analysis, particularly 1D and 2D NMR and HRESIMS, whereas the absolute configurations were determined by a combination of ECD and NMR calculations coupled with a DP4+ probability analysis.

Cytotoxic prenylated xanthone derivatives from the twigs of .

A new prenylated xanthone, kaennacowanol D (), was isolated from the twigs of together with 22 known analogs. The structure of the new metabolite was elucidated by extensive spectroscopic analysis, particularly using HRMS and NMR. Kaennacowanol D is the first example of a natural xanthone containing a levulinyl group incorporated at the terminal prenyl unit ester bond.

Cytotoxic Polyprenylated Benzoylphloroglucinol Derivatives from the Branches of Garcinia schomburgkiana.

Five undescribed polyprenylated benzoylphloroglucinol derivatives (1:  - 5: ), named garschomcinols A - E, and five known analogues (6:  - 10: ) were isolated from the branches of . Their structures were determined on the basis of 1D and 2D NMR and HRESIMS analyses. The absolute configuration of the bicyclo [3.

Cytotoxic and Anti-Inflammatory Activities of Dihydroisocoumarin and Xanthone Derivatives from .

, a woody plant native to Sulawesi and Maluku Islands, Indonesia, has been traditionally used as a wound healing ointment. In our continuous search for bioactive compounds from this plant, 15 phenolic compounds were isolated from its stem bark, including a previously undescribed dihydroisocoumarin, 2'-hydroxyannulatomarin, and two undescribed furanoxanthones, gerontoxanthone C hydrate and 3'-hydroxycalothorexanthone. The structures of the new metabolites were elucidated on the basis of spectroscopic analysis, including 1D and 2D NMR and HRESIMS.

Picrorhizones A-H, Polyprenylated Benzoylphloroglucinols from the Stem Bark of .

Eight new polyprenylated benzoylphloroglucinol derivatives (-) and four known analogues (-) were isolated from the stem bark of . Their structures were determined by spectroscopic data analysis (1D and 2D NMR and HRESIMS), and the absolute configurations were established by single-crystal X-ray diffraction combined with experimental and calculated ECD data. The new metabolites represent rare examples of benzoylphloroglucinols bearing a cyclobutyl-containing side chain.

Velucarpin D, a new pterocarpan from the stems of and its cytotoxicity.

A new pterocarpan, named velucarpin D (), along with nine known pterocarpans () were isolated from the stems of . Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines (KB, HeLa S-3, MCF-7, Hep G2, and HT-29).

Correction to: Two new xanthones from the roots of Cratoxylum cochinchinense and their cytotoxicity.

In the original publication of the article, figure 1 was published incorrectly. The correct version of figure 1 is provided below.

Two new xanthones from the roots of Cratoxylum cochinchinense and their cytotoxicity.

Two new xanthones namely cratochinone A (1) and cratochinone B (2), along with 16 known xanthones, were isolated from the roots of Cratoxylum cochinchinense. Their structures were characterized by spectroscopic methods, especially 1D and 2D NMR as well as comparison with those reported in the literature for known xanthones. All isolated compounds were evaluated for their cytotoxicity against five human cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and Hep G2 cell lines).

Tetrandraxanthones A-I, Prenylated and Geranylated Xanthones from the Stem Bark of Garcinia tetrandra.

Nine new xanthones, tetrandraxanthones A-I (1-9), and 22 known xanthones (10-31) were isolated from Garcinia tetrandra stem bark. The structures of 1-9 were characterized through detailed spectroscopic analysis, including HRESIMS and 2D NMR data. Among the compounds tested for their cytotoxicity, 26 showed significant cytotoxic effects against five human cancer cell lines, including MCF-7, HT-29, KB, Hep G2, and HeLa S3, with IC values in the range of 1.

Veluflavanones A-P, Cytotoxic Geranylated Flavanones from Dalbergia velutina Stems.

Sixteen new geranylated flavanones, named veluflavanones A-P (1-16), and a known analogue (17), were isolated from Dalbergia velutina. The chemical structures of 1-17, as well as their absolute configurations, were determined by spectroscopic analysis and experimental ECD data. All isolated compounds were tested for their cytotoxicity against five human cancer cell lines.

Two new xanthones and cytotoxicity from the bark of Garcinia schomburgkiana.

Two new xanthone derivatives, named schomburgones A (1) and B (2), along with eight known compounds, including xanthones (3-8) and anthraquinones (9-10) were isolated from the bark of Garcinia schomburgkiana. Their structures were determined by spectroscopic analysis especially 1D and 2D NMR spectroscopies. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and HepG-2).

Xanthones and biphenyls from the stems of Garcinia cylindrocarpa and their cytotoxicity.

Six new compounds including four new xanthones, cylindroxanthones D-G (1-4), and two new biphenyls, cylindrobiphenyls A and B (5 and 6), were isolated from the stems of Garcinia cylindrocarpa together with 28 known compounds (7-34). The structures of the new compounds were established on the basis of extensive 1D and 2D NMR and HRESIMS spectroscopic analysis. Their cytotoxicity was evaluated against five human cancer cell lines including KB, HeLa S-3, MCF-7, Hep G2, and HT-29.

Calaxanthones A-C, three new xanthones from the roots of and the cytotoxicity.

Three new xanthones, named calaxanthones AC (-), along with 17 known xanthones (-) were isolated from the roots of . Their structures were determined by spectroscopic analysis. All isolated compounds were evaluated for their cytotoxicity against five cancer cell lines (KB, HeLa S-3, HT-29, MCF-7 and HepG-2).

Catomentosaponin, a new triterpene saponin from the roots of Catunaregam tomentosa.

A new triterpene saponin, catomentosaponin (1) and 11 known analogues (2-12) were isolated from the roots of Catunaregam tomentosa. The structures of 1-12 were determined on the basis of extensive NMR and MS data analysis. The sugar residues were identified by co-TLC and HPLC analysis after hydrolysis.