Publications by authors named "Kitahata S"
Allergic diseases and ulcerative colitis (UC) share pathophysiological similarities. This study aimed to investigate the unclear association between allergic diseases and mucosal healing (MH), an important factor in the prognosis of UC. We studied 289 Japanese patients with UC.
View Article and Find Full Text PDFPurpose: To investigate the association between the thickness of the retinal pigment epithelium (RPE)-Bruch's membrane (BM) complex and the development of retinal autograft edema as a postoperative complication following autologous retinal transplantation (ART).
Methods: This retrospective study examined data from 28 eyes of 28 patients (14 males, 14 females; mean age, 61.5 ± 19.
Article Synopsis
- The study investigates the challenges of selective biliary cannulation during endoscopic retrograde cholangiopancreatography (ERCP), focusing on how different papillary morphologies can complicate the process.
- Researchers analyzed data from 776 patients to identify risk factors for cannulation difficulties, finding that certain types of papillae, the presence of periampullary diverticulum (PAD), and scope operability significantly impacted success rates.
- The study concluded that specific patterns can predict cannulation difficulties, helping to inform whether to use conventional or salvage techniques in treatment.
Purpose: To evaluate retinal circulation in eyes with central retinal artery occlusion.
Methods: The best-corrected visual acuity (BCVA), fluorescein angiography, and laser speckle flowgraphy values were measured at the first visit in 42 patients with central retinal artery occlusion (42 eyes; mean age, 66.0 ± 14.
Article Synopsis
- Nocturia, or frequent nighttime urination, is a common symptom in patients with lower urinary tract syndrome (LUTS), and its link to ulcerative colitis (UC) has not been widely studied.
- A study was conducted with 287 Japanese UC patients, who were categorized based on their nighttime urination frequency and evaluated for mucosal healing (MH) and clinical remission (CR) using survey data.
- Results indicated that higher frequencies of nighttime urination are associated with lower rates of mucosal healing, particularly in younger patients and those in clinical remission, suggesting that nocturia could be a potential indicator of disease status in UC patients.
Socioeconomic status is a risk factor for poor disease prognosis. No studies of patients with ulcerative colitis (UC) have investigated the association between socioeconomic status and erectile dysfunction (ED), although UC is independently positively associated with ED. Therefore, the purpose of this survey to evaluate this issue in Japanese patients with UC.
View Article and Find Full Text PDFDevelopment of selective or dual proteasome subunit inhibitors based on syringolin B as a scaffold is described. We focused our efforts on a structure-activity relationship study of inhibitors with various substituents at the 3-position of the macrolactam moiety of syringolin B analogue to evaluate whether this would be sufficient to confer subunit selectivity by using sets of analogues with hydrophobic, basic and acidic substituents, which were designed to target Met45, Glu53 and Arg45 embedded in the S1 subsite, respectively. The structure-activity relationship study using systematic analogues provided insight into the origin of the subunit-selective inhibitory activity.
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- The study examines changes in characteristics of hospitalized patients in Japan from 2010 to 2021, highlighting issues related to the country's aging population.
- Data from nearly 24,000 inpatients show an increase in patients aged over 75 and a rise in emergency admissions over the years.
- Notably, there was a decline in liver disease cases and a significant increase in biliary-pancreatic conditions and malignancies during the study period.
The association between ulcerative colitis (UC) and erectile dysfunction (ED) has been previously reported. Numerous previous studies have also reported an association between gastrointestinal symptoms and ED. Constipation and diarrhea are common in patients with UC.
View Article and Find Full Text PDFBackground/aim: Unresectable recurrence after curative treatments for hepatocellular carcinoma (HCC) is a life-limited event. Although the IMbrave050 trial (IM050) showed a favorable reduction in recurrence with adjuvant immune-combination chemotherapy, inclusion criteria of the radiofrequency ablation (RFA) group were lower risk than that of the resection group. This study aimed to elucidate the clinical features of patients treated with RFA, which really need adjuvant-chemotherapy.
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- The retinal pigment epithelium (RPE) is crucial for eye health and its dysfunction can lead to visual disorders, making hiPSC-RPE transplantation a potential therapy for conditions like age-related macular degeneration.* -
- Gelatin hydrolysate was tested to improve hiPSC-RPE transplantation by reducing cell reflux, boosting cell viability, and decreasing inflammation, demonstrating beneficial effects on cell behavior and performance in a lab setting.* -
- The study concludes that gelatin hydrolysate may significantly enhance the success of hiPSC-RPE therapies, making it a promising candidate for future regenerative treatments in vision-related disorders.*
Objective: Cystoid macular edema (CME) in retinitis pigmentosa (RP) is an important complication causing visual dysfunction. We investigated the effect of CME on photoreceptors in RP patients with previous or current CME, using an adaptive optics (AO) fundus camera.
Methods: We retrospectively observed the CME and ellipsoid zone (EZ) length (average of horizontal and vertical sections) by optical coherence tomography.
Age is a risk factor for constipation. Constipation is common in patients with ulcerative colitis (UC) and has been positively associated with disease activity, but evidence is limited. This study aimed to assess the association between disease activity and constipation in patients with UC.
View Article and Find Full Text PDFObjective: Recently, a close association between ulcerative colitis (UC) and erectile dysfunction (ED) was reported. An inverse relationship between serum albumin and ED is found in patients with chronic disease. However, the association between serum albumin levels and ED in patients with UC is unclear.
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- The Virtual Baveno VII Consensus Workshop suggested a method to predict esophagogastric varices (EGVs) using liver stiffness and platelet counts, but this method requires equipment not available everywhere.
- The study analyzed 1,090 patients with hepatocellular carcinoma to identify clinical factors predicting significant EGV, focusing on simple blood tests rather than specialized equipment.
- Key findings established a REGS score based on platelet count and mALBI grades, allowing for EGV prediction without needing advanced tools, demonstrating increasing risk with higher REGS scores.
No reports of renal cancer in patients with Wilson's disease (WD) exist. We herein report a 37-year-old Japanese man diagnosed with WD who had been treated with d-penicillamine 9 years prior. Hepatocellular carcinoma had been diagnosed at 36 years old and treated with radiofrequency ablation therapy.
View Article and Find Full Text PDFObjective: To investigate the association between nocturia and constipation in patients with ulcerative colitis (UC). Constipation has recently been recognized as an important symptom in patients with UC. Although nocturia has been associated with constipation in the general population, the association between nocturia and constipation in UC patients is uncertain.
View Article and Find Full Text PDFIntroduction: The aMAP score is a prediction model for hepatocellular carcinoma (HCC) risk in chronic hepatitis patients. This study was conducted to elucidate the utility of this model for predicting initial recurrence of HCC in patients within the Milan criteria after undergoing curative treatment.
Methods: Patients with naïve HCC within the Milan criteria (n = 1,020) and treated from January 2000 to August 2022 were enrolled.
Background/Aim: For intermediate-stage hepatocellular carcinoma (HCC) (Barcelona Clinic Liver Cancer [BCLC]-B) cases, transarterial chemoembolization (TACE) is recognized as the standard treatment, while systemic therapy is recommended for TACE-unsuitable HCC. However, because the curative potential is not high, this study was conducted to elucidate the potential outcomes of surgical resection (SR) for BCLC-B HCC cases. Materials/Methods: From January 2000 to July 2022, 70 patients with BCLC-B HCC treated with surgery as the initial treatment were enrolled (median age 67.
View Article and Find Full Text PDFPurpose: To evaluate the relationship between retinal haemorrhages detected on Ultra-widefield (UWF) red channel images and perfusion status in eyes with acute central retinal vein occlusion (CRVO).
Methods: UWF fundus images were split into green and red channels using ImageJ software. The retinal haemorrhages were calculated quantitatively with both the green and red channel images, resulting in green channel haemorrhages (GCH) and red channel haemorrhages (RCH).
Article Synopsis
- - This study examined how the structure of transplanted retinal grafts and visual acuity (VA) changed over time in patients who had autologous retinal transplantation (ART) for large macular holes (MHs).
- - Seventeen patients were included, and results showed that while the thickness and area of the grafts decreased, their overall structure improved, with 52.9% of patients demonstrating a presence of the ellipsoid zone (EZ), which was linked to better visual outcomes.
- - Overall, all patients achieved closure of the macular holes, and VA improved significantly after one year, indicating positive outcomes from ART despite some morphological changes in the grafts.
Introduction: Recent meta-analysis showed that ulcerative colitis (UC) is a risk factor for cardiovascular disease (CVD). Dyslipidemia is a well-established risk factor for CVD. However, evidence regarding inflammatory bowel disease (IBD), including UC and lipid profiles, is limited.
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