Publications by authors named "Kitagawa Y"
Objective: To evaluate the satisfaction, effectiveness, and usability of a telerehabilitation programme for Parkinson's disease (PD) patients.
Design: Prospective cohort study.
Subjects/patients: PD patients based on the diagnostic criteria for clinically established or probable PD published by the International Parkinson and Movement Disorder Society.
Chronic complete spinal cord injury (SCI) is difficult to treat because of scar formation and cavitary lesions. While human iPS cell-derived neural stem/progenitor cell (hNS/PC) therapy shows promise, its efficacy is limited without the structural support needed to address cavitary lesions. Our study investigated a combined approach involving surgical scar resection, decellularized extracellular matrix (dECM) hydrogel as a scaffold, and hNS/PC transplantation.
View Article and Find Full Text PDFObjectives: Lockdowns and outing restrictions during the COVID-19 pandemic may have altered attitudes towards hospital visits. This study aimed to investigate changes in long-distance visits outside of secondary healthcare service areas (SHSA) among cancer patients in Japan.
Design: Retrospective observational study.
Background/objectives: This study aimed to evaluate the safety, efficacy, and long-term outcomes of S-1-based neoadjuvant chemoradiotherapy (NACRT) in patients with resectable or borderline-resectable pancreatic ductal adenocarcinoma (PDAC).
Methods: This retrospective study included patients with PDAC who underwent S-1-based NACRT at our institute between 2010 and 2017.
Results: Forty patients were included in the study, including 15 (37.
Background: Lymphovascular invasion (LVI) or pT1b is noncurative after endoscopic resection (ER) for esophageal squamous cell carcinoma (ESCC), and therefore surgery or chemoradiotherapy (CRT) is recommended. However, there has been debate regarding which treatment has better outcomes and whether individual risks should be considered.
Methods: This was a multicenter, retrospective study conducted at 65 hospitals in Japan.
Background: The COVID-19 pandemic had a profound impact on cancer screening, diagnosis, and treatment procedures. We speculated that during the COVID-19 pandemic, sufficient medical resources were maintained in board-certified hospitals, resulting in favorable short-term outcomes, whereas hospital functions in non-board-certified hospitals declined, leading to mortality increase. The aim of this study is to investigate the impact of COVID-19 pandemic on short-term outcomes after esophagectomy, based on the scale of the facilities.
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- Singlet fission (SF) is a process that turns one singlet exciton into two triplet excitons, which can enhance energy transfer in materials.
- The study explored SF dynamics in specific linear heterotrimer systems made from different pentacene derivatives to understand how substituents affect exciton behavior.
- The findings suggest that appropriate substituent choices can significantly increase the efficiency of triplet exciton migration due to quantum interference effects that emerge from reduced structural symmetry.
Pyogenic granuloma is a nonneoplastic inflammatory reactive hyperplasia commonly found in the soft tissues of the skin and oral mucosa. Oral pyogenic granulomas are usually found on the lips, gingiva, and tongue, but rarely on the palate. Surgical excision is the standard treatment for oral pyogenic granulomas.
View Article and Find Full Text PDFBackground: Despite recent medical advancements, surgery for hilar cholangiocarcinoma is associated with high complication and mortality rates. This may be partly attributed to the absence of established preoperative liver evaluation criteria for safe surgery. This study aimed to propose a reliable indicator for safe and well-planned management of major hepatectomy with extrahepatic bile duct resection.
View Article and Find Full Text PDFBackground: Peritoneal metastasis, a major complication of colorectal cancer (CRC), often leads to poor quality of life and unfavorable outcomes. Despite numerous studies characterizing its biological features in CRC, intratumor heterogeneity and interactions between cancer cells and tumor microenvironment cells remain poorly understood.
Methods: To explore these aspects, we performed single-cell transcriptome analysis of matched primary tumor and peritoneal metastasis samples from a treatment-naïve patient.
Purpose: Adjuvant chemotherapy (AC) for stage III disease is recognized as a standard treatment and is routinely performed in patients with colon cancer (CC). However, the recommendation for AC is mainly based on studies performed in past environments, where D3 lymphadenectomy was not routinely performed.
Methods: We retrospectively analyzed CC patients who underwent curative resection with D3 lymphadenectomy in Keio Surveillance Epidemiology and End Results (K-SEER) database.
Successful surgical treatment for aortoenteric fistula after esophagectomy: a case report.
Gen Thorac Cardiovasc Surg Cases
July 2024
Background: An aortoenteric fistula (AEF) is a rare and lethal complication of esophagectomy. Fistulas frequently result from problems regarding acute infections or leaks, which are typically evident weeks after the treatment. However, some cases exhibit AEF years after the initial operation.
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- Enfortumab Vedotin (EV) is an effective treatment for advanced urothelial carcinoma (UC) patients who have already undergone other therapies, but there’s limited understanding of the factors that impact patient outcomes.
- A retrospective study was conducted to identify clinical factors affecting progression-free survival (PFS) and overall survival (OS) in these patients, leading to the development of a new risk classification model based on identified prognostic factors.
- The study found that high levels of C-reactive protein and hypercalcemia were significant predictors of patient outcomes, allowing for the classification of patients into three distinct risk groups, which showed notable differences in survival rates.
Article Synopsis
- Tumor stiffness is being recognized as a new diagnostic parameter, separate from traditional pathological assessments.
- Researchers developed a laser resonance frequency analysis (L-RFA) method that measures stiffness differences between tumor and normal tissues, making it an effective tool for diagnosing gastric cancer.
- Tests showed clear correlations in stiffness measurements, indicating that L-RFA can distinguish between tumor and normal tissue with significant accuracy, highlighting its potential as a noninvasive diagnostic approach.
Article Synopsis
- Trivalent europium (Eu(III)) complexes emit bright luminescence due to energy transfer from antenna ligands, specifically bidentate β-diketonates, although the mechanism was not fully understood before this study.
- The researchers employed time-resolved photoluminescence and femtosecond transient absorption spectroscopy to detail the energy transfer steps in the [Eu(hfa)(TPPO)] complex, revealing processes like intersystem crossing and energy transfer to Eu(III).
- Their findings show that direct bonds in bidentate ligands promote efficient energy transfer, and understanding these processes can help in designing better luminescent materials for future research.
Background: Postoperative complications like remnant hepatic vein (HV) outflow block and liver torsion can occur after right hepatectomy. Hepatic falciform ligament fixation is typically used to prevent liver torsion. We report a novel procedure to manage outflow block.
View Article and Find Full Text PDFMedication-related osteonecrosis of the jaws (MRONJ) has emerged as one of the major adverse effects of antiresorptive agents in the treatment of patients with cancer and osteoporosis. MRONJ presents as a chronic inflammation of the maxillary and/or mandibular bones accompanied by necrotic bone exposure and intra-/extraoral fistula. Given the increasing number of patients with MRONJ, surgical treatment is highlighted to be significantly beneficial for those patients.
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- The review focuses on prevention and treatment strategies for COVID-19, highlighting the role of SARS-CoV-2 mutations in creating variants that evade immunity and some antiviral resistance.
- It identifies 150 natural metabolites and botanical drug-derived bioactive molecules that may offer more effective and less toxic alternatives for COVID-19 treatment, including Thai and Chinese traditional medicine approvals.
- The text emphasizes the impact of long COVID on about 10% of patients and suggests that botanical adjuvants, including vitamin C and E, might help alleviate symptoms and reduce the risk of long COVID progression.
Article Synopsis
- * The research involved a multicenter point-prevalence survey of 10,199 patients across 27 hospitals in Aichi Prefecture, revealing a 6.6% rate of HAIs, with pneumonia, urinary tract infections, and surgical site infections being the most common.
- * The study concludes that the findings are crucial for understanding HAIs in Japan and stresses the importance of national-level surveys to monitor healthcare challenges, especially in the context of post-COVID-19 conditions.
Article Synopsis
- - The study evaluated the effectiveness and safety of adding adjuvant S-1 chemotherapy after surgery in patients with locally advanced esophageal squamous cell carcinoma (ESCC) who previously received neoadjuvant chemotherapy followed by surgery (NAC-S).
- - A total of 52 patients participated, with a reported 3-year relapse-free survival rate of 72.3% and overall survival rate of 85.0%, indicating successful outcomes for the primary endpoint.
- - The treatment had some side effects, with the most common grade ≥3 adverse events being neutropenia, anorexia, and diarrhea; however, no treatment-related deaths occurred, suggesting it is a safe option worth exploring further.