Effect of Blood Orange ( L. Osbeck) Peel Waste as a Feed Additive on the Growth Performance, Digestive Enzyme Activity, Antioxidant Capacity, and Immune Response in Juvenile Black Rockfish ().

This study evaluated bioactive compounds in blood orange ( (L.) Osbeck) peel (BOP) as dietary additives. An 8-week feeding trial was conducted to investigate the effects of dietary supplementation on the growth performance, body composition, digestive enzyme activity, antioxidant capacity, and immune response of juvenile black rockfish.

Neurotoxic effects of citronellol induced by the conversion of kynurenine to 3-hydroxykynurenine.

Citronellol is widely utilized in consumer products, including cosmetics, fragrances, and household items. However, despite being considered a relatively safe chemical, the health effects and toxicity mechanisms associated with exposure to high concentrations of citronellol, based on product content, remain inadequately understood. Here, we aimed to analyze the neurological effects of citronellol in zebrafish larvae using behavioral and histological analyses and elucidate the mechanisms underlying its neurotoxicity in vivo.

Organophosphate flame retardants and their metabolites in paired dog food and urine: Pet exposure through food consumption.

Companion dogs are exposed to various chemicals. However, our understanding of the sources and pathways of chemical exposure in pets remains limited. In this study, we collected urine samples from 47 dogs and corresponding samples of the food they consumed to analyze the concentrations and dietary exposure to organophosphate flame retardants (OPFRs) and their metabolites (mOPFRs).

Fruit Extract Suppresses Lipopolysaccharide-Induced Neuroinflammation in BV-2 Microglia Cells via the MAPK and NF-B Signaling Pathways.

Hedl. is a traditional medicinal plant in Korea, China, and Japan with known antioxidative, anti-inflammatory, anti-atherogenic, and anti-melanin activities. However, its anti-neuroinflammatory effects remain largely unknown.

Robotic repair of atrial septal defect: Pre-groove vertical right atriotomy approach.

Objective: Minimally invasive repair using robotic systems has been accepted as an attractive alternative in the surgical repair of atrial septal defects (ASDs). Clear exposure of the entire rim of the ASD is often hindered during a robotic approach. Here, we describe an approach using vertical right atriotomy along the interatrial groove that may enhance the exposure of the ASD.

An AIE-based fluorescent dye for selective staining of polyamide microplastics without pretreatment: Applications to environmental samples and zebrafish.

A novel staining dye, BEM ((1E,1'E)-1,1'-([2,2'-bithiophene]-5,5'-diyl)bis(N-(9-ethyl-9H-carbazol-3-yl)methanimine)) was synthesized for selective identification of polyamide (PA) micrplastics. BEM showed unique photophysical properties such as solvatochromism, intramolecular charge transfer (ICT), and aggregation induced emission (AIE) which were demonstrated through spectroscopic analysis and density functional theory (DFT) calculations. The optimal staining conditions for selective staining of PA by BEM were established by evaluating the staining efficiency according to the variation of the solvent compositions, concentrations of BEM, and staining durations.

Multi-bioapplicable fluorescence chemosensor for sequentially identifying gallium ion and pyrophosphate: Application to environmental samples, human serum, zebrafish and celery.

A multi-bioapplicable fluorescence chemosensor MQV, ((E)-2-methoxy-6-((2-(quinolin-2-yl)hydrazineylidene)methyl)phenol), was developed for sequential detection of Ga and pyrophosphate (PPi) ions. The addition of Ga and PPi to MQV in sequence strongly caused an off-on-off fluorescent response in PBS buffer/DMSO (8:2, v/v, pH 7.4).

Comparison of urinary exposure profiles to phthalates and bisphenol analogues in kindergartens in Korea: Impact of environmental choices on children's health.

Phthalates and bisphenols (BPs) are well-known endocrine disrupting chemicals (EDCs) that are widely used in diverse consumer and personal care products. Despite their vulnerability, children are frequently exposed to phthalates and BPs in their surrounding environments. Although pre-school children spend most of their time in kindergarten, no comprehensive assessment of children' exposure to EDCs has been conducted according to the type of kindergarten.

Comparative Genomics Reveals Species-Specific Genes and Symbiotic Adaptations in .

, a highly valued ectomycorrhizal fungus, requires a symbiotic relationship with pine trees for growth, complicating its cultivation. This study presents a comprehensive comparative genomic analysis of species, with a focus on . Genomic data from 19 assemblies representing 13 species were analyzed to identify genus-, species-, and strain-specific genes, revealing significant evolutionary adaptations.

Prognostic impact of mild renal dysfunction in patients undergoing valve surgery.

Objectives: To analyse the impact of mild renal dysfunction on the prognosis of patients undergoing valve surgery.

Methods: A total of 6210 consecutive patients (3238 women; mean age 59.2 ± 12.

Rivaroxaban for 18 Months Versus 6 Months in Patients With Cancer and Acute Low-Risk Pulmonary Embolism: An Open-Label, Multicenter, Randomized Clinical Trial (ONCO PE Trial).

Background: The optimal duration of anticoagulation therapy for patients with cancer and acute low-risk pulmonary embolism (PE) is clinically relevant, but evidence is lacking. Prolonged anticoagulation therapy could have a potential benefit for prevention of thrombotic events; however, it could also increase the risk of bleeding.

Methods: In a multicenter, open-label, adjudicator-blinded, randomized clinical trial at 32 institutions in Japan, we randomly assigned patients with cancer and acute low-risk PE of the simplified version of the Pulmonary Embolism Severity Index score of 1, in a 1:1 ratio, to receive either an 18-month or a 6-month rivaroxaban treatment.

Nuclear localization sequence of MoHTR1, a Magnaporthe oryzae effector, for transcriptional reprogramming of immunity genes in rice.

Plant pathogens secrete nuclear effectors into the host nuclei to modulate the host immune system. Although several nuclear effectors of fungal pathogens have been recently reported, the molecular mechanism of NLS-associated transport vehicles of nuclear effectors and the roles of NLS in transcriptional reprogramming of host immunity genes remain enigmatic. We previously reported the MoHTR1, a nuclear effector of the rice blast fungus, Magnaporthe oryzae.

Use of the Puccinia sorghi haustorial transcriptome to identify and characterize AvrRp1-D recognized by the maize Rp1-D resistance protein.

The common rust disease of maize is caused by the obligate biotrophic fungus Puccinia sorghi. The maize Rp1-D allele imparts resistance against the P. sorghi IN2 isolate by initiating a defense response that includes a rapid localized programmed cell death process, the hypersensitive response (HR).

A novel simultaneous abatement of bromate and diphenyl phosphate using the freezing process.

The purification of bromate (BrO)-contaminated water has become a challenge because of its persistence and adverse effects. Furthermore, there has been concern over the release of byproducts, such as diphenyl phosphate (DPHP), from flame retardants in wastewater treatment plant (WWTP). In this study, we designed the water treatment system for the oxidation of DPHP accompanied by bromate (BrO) reduction via freezing the solution.

Exploring micropollutants in polar environments based on non-target analysis using LC-HRMS.

The routine use of chemicals in polar regions contributes to unexpected occurrence of micropollutants, with sewage discharge as a prominent pollution source. The aim of this study was to identify and quantify micropollutants in polar environments near potential point sources using non-target analysis (NTA) with liquid chromatography high-resolution mass spectrometry. Seawater samples were collected from Ny-Ålesund, Svalbard and Marian Cove, King George Island, in 2023.