Publications by authors named "Kistie B Patch"
Article Synopsis
- The genetic basis for phenotypic variation can differ greatly between populations, especially if founded by a small number of genotypes.
- Different traits, such as resistance to various pathogens, may share some genetic similarities (pleiotropy) or exhibit distinct genetic profiles indicating context-dependent selection.
- A study on Drosophila's immune response to two different pathogens showed no shared genetic architecture for bacterial resistance but identified a common QTL peak related to immune genes, suggesting natural selection could influence these genes for both pathogens.
Meiotic drivers are selfish genetic elements that tinker with gametogenesis to bias their own transmission into the next generation of offspring. Such tinkering can have significant consequences on gametogenesis and end up hampering the spread of the driver. In Drosophila affinis, sex-ratio meiotic drive is caused by an X-linked complex that, when in males with a susceptible Y chromosome, results in broods that are typically more than 95% female.
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- Sap-sucking insects, like adelgids, rely on symbiotic bacteria to obtain essential nutrients from their plant-sap diets, as they have complex life cycles involving different conifer trees.
- The study examined the consistency of bacterial symbionts across various adelgid lineages and discovered that distinct pairs of symbionts were consistently associated with each adelgid species.
- Evidence suggested these symbionts are likely long-term obligate mutualists, including their presence in eggs for vertical transmission, and shared characteristics seen in other long-lasting symbionts.
Nitric oxide (NO) mediates host resistance to severe malaria and other infectious diseases. NO production and mononuclear cell expression of the NO producing enzyme-inducible nitric oxide synthase (NOS2) have been associated with protection from severe falciparum malaria. The purpose of this study was to identify single nucleotide polymorphisms (SNPs) and haplotypes in the NOS2 promoter, to identify associations of these haplotypes with malaria severity and to test the effects of these polymorphisms on promoter activity.
View Article and Find Full Text PDFBackground: Exhaled breath condensate (EBC) pH and exhaled nitric oxide (FeNO) have been proposed as markers of asthma severity. EBC pH values below 6.5 have been associated with asthma exacerbations.
View Article and Find Full Text PDFBackground: Asthma is a significant cause of morbidity and mortality for African Americans. Fraction of exhaled nitric oxide (FeNO) levels are increased in patients with asthma, and airway levels of nitric oxide metabolites regulate airway inflammation and airway diameter. More needs to be known about the factors that regulate FeNO.
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