A rare case of type II tri-allelic inheritance at vWA, SE33, D8S1179, and D13S317 loci demonstrated by STR analysis in paternity testing.

Short tandem repeat (STR) typing has been regularly used in paternity disputes and forensic human identification linked caseworks. Occasionally, forensic scientists come across aberrant allele patterns during STR typing because of mutations, genetic variations, and other abnormalities. The tri-allelic pattern of STR is rare, particularly, the case where this pattern exists at 4 loci.

Iminosugars Spiro-Linked with Morpholine-Fused 1,2,3-Triazole: Synthesis, Conformational Analysis, Glycosidase Inhibitory Activity, Antifungal Assay, and Docking Studies.

Synthesis of iminosugars , , , and and N-alkyl (ethyl, butyl, hexyl, octyl, decyl, and dodecyl) derivatives - and - spiro-linked with morpholine-fused 1,2,3-triazole is described. Conformation of the piperidine ring in each spiro-iminosugar was evaluated by H NMR spectroscopy, and conformational change in N-alkylated compounds - with respect to parent spiro-iminosugar is supported by density functional theory calculations. Out of 16 new spiro-iminosugars, the spiro-iminosugars (IC = 0.

α-Geminal disubstituted pyrrolidine iminosugars and their C-4-fluoro analogues: Synthesis, glycosidase inhibition and molecular docking studies.

A simple strategy for the synthesis of α-geminal disubstituted pyrrolidine iminosugars 3a-c and their C-4 fluorinated derivatives 4a-c has been described from d-glucose. The methodology involves the Corey-Link and Jocic-Reeve reaction with 3-oxo-α-d-glucofuranose and nucleophilic displacement reaction to get the furanose fused pyrrolidine ring skeleton with requisite CHOH/COH functionalities at C-3. The fluorine substituent in target molecules was introduced by nucleophilic displacement of -OTf in 9a/9c with CsF.

Azetidine- and N-carboxylic azetidine-iminosugars as amyloglucosidase inhibitors: synthesis, glycosidase inhibitory activity and molecular docking studies.

A simple strategy for the synthesis of hitherto unknown azetidine iminosugars 2a–2c and N-carboxylic azetidine iminosugar 2d has been reported. The methodology involves the conversion of 1,2:5,6-di-O-isopropylidene-3-oxo-α-D-glucofuranose 3 to 3-azido-3-deoxy-3-C-(formyl)-1,2:5,6-di-O-isopropylidene-α-D-glucofuranose 5 using the Jocic–Reeve and Corey–Link approaches. Compound 5 was transformed to 5-OTs 10/5-OMs 19 derivatives that on intramolecular nucleophilic displacement with in situ generated 3-amino functionality afforded the key azetidine ring skeletons 11 and 20, respectively.