Publications by authors named "Kishor Kumar Mandal"
Herein, we disclose the asymmetric total synthesis of 1'-deshydroxymethyl analogues of naturally occurring aporpinone A, aporpinone B, and 4'-hydroxyaporpinone A, featuring a γ--alkylidene butenolide framework. Bimetallic (Pd-Cu) cascade cyclization on a properly functionalized bis-alkyne with -2-bromoacrylic acid was employed to construct the butenolide framework with an alkyne appendage. Late-stage enzymatic kinetic resolution (EKR) was adopted for the synthesis of ()-1'-deshydroxymethyl aporpinone A and ()-1'-deshydroxymethyl acetyl aporpinone A.
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- This article discusses the total synthesis of specific naturally occurring isocoumarins, including 2'-methoxydihydroartemidin and ()-3'-hydroxyartemidin, using a unique method.
- The synthesis involves an efficient and selective cyclization process of 2-halobenzoic acids and chiral terminal alkynes, facilitated by ligand-free Cu(I) catalysis.
- The research includes in-depth mechanistic studies, revealing that the solvent plays a crucial role in directing the reaction pathway, leading to the successful synthesis of various small molecular entities from the isocoumarins.