In silico evaluation of bisphosphonates identifies leading candidates for SARS-CoV-2 RdRp inhibition.

The novel coronavirus disease (COVID-19) pandemic has resulted in 777 million confirmed cases and over 7 million deaths worldwide, with insufficient treatment options. Innumerable efforts are being made around the world for faster identification of therapeutic agents to treat the deadly disease. Post Acute Sequelae of SARS-CoV-2 infection or COVID-19 (PASC), also called Long COVID, is still being understood and lacks treatment options as well.

Comparative Evaluation of Soft Tissue Chin Thickness in Adult Patients with Skeletal Class II Malocclusion with Various Vertical Growth Patterns: a Cephalometric Study.

Introduction: Facial soft tissue thickness is important not only for plastic surgeons but also for orthodontists to plan the treatment procedure. Genioplasty, an orthognathic surgery in combination with orthodontic treatment is indicated to restore adequate shape and projection of the chin in the face. It has been performed to enhance soft tissue contours related to disproportion between soft and hard tissue.