Publications by authors named "Kishan Ughreja"
Background: Right ventricular (RV) failure is a major cause of mortality worldwide and is often a consequence of RV pressure overload (RVPO). Endoglin is a coreceptor for the profibrogenic cytokine, transforming growth factor beta 1 (TGF-β1). TGF-β1 signaling by the canonical transient receptor protein channel 6 (TRPC-6) was recently reported to stimulate calcineurin-mediated myofibroblast transformation, a critical component of cardiac fibrosis.
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- Right ventricular (RV) failure significantly contributes to mortality in lung disease and left heart failure; this study aimed to analyze biventricular hemodynamics and the expression of proteins involved in cardiac remodeling in mouse models of RV pressure overload (RVPO).
- Male mice were subjected to pulmonary artery or thoracic aorta constriction, and measurements were taken on RV and left ventricular function, as well as tissue analysis for changes in cardiac structure like hypertrophy and fibrosis.
- Results showed differing impacts of primary and secondary RVPO on biventricular function, with variations in stroke work, pressure dynamics, and cardiac remodeling proteins (calcineurin and TGFβ1), highlighting unique responses in heart structure and function between the two types