[Optical coherence tomography angiography in the differential diagnosis of iris melanoma and progressive iris nevus].

Unlabelled: Considering the similarity in clinical presentations of iris neoplasms of various origins, questions of their noninvasive diagnosis remain relevant. Optical coherence tomography angiography (OCT-A) is one of the imaging method that enables visualization of tumor vessels.

Purpose: This article examines the features of angioarchitecture, vascular network density, and perfusion density of iris melanoma and progressive iris nevus using OCT-A.

[Intravenous thrombolytic therapy of ischemic stroke with the drug Revelisa in real clinical practice: results of the IVT-AIS-R study].

Objective: Evaluation of the safety and effectiveness of thrombolytic therapy (TLT) with the drug Revelisa (alteplase) in patients with ischemic stroke (AI) in real clinical practice.

Material And Methods: An open prospective multicenter non-interventional register study was conducted, which included 550 patients with AI - 259 (47.1%) women and 291 (52.

[Use of optical coherence tomography angiography in assessment in conjunctival vascular architecture in health and pathology].

Purpose: Investigation of the capabilities of anterior segment (AS) optical coherence tomography angiography (OCTA) in evaluation of conjunctival vascular architecture in healthy individuals and in various pathological conditions.

Material And Methods: The study included 17 healthy volunteers (34 eyes; the control group) and 62 patients (68 eyes) with conjunctival lesions of various nature. All participants underwent AS-OCT and AS-OCTA with assessment of qualitative (vessels pattern, lumen, pathologic tortuosity) and quantitative parameters (vessel density (VD, %) in the lesion area).

Size-Dependent Structural, Magnetic and Magnetothermal Properties of YFeO Fine Particles Obtained by SCS.

Iron-containing oxides are the most important functional substance class and find a tremendous variety of applications. An attractive modern application is their use in biomedical technologies as components in systems for imaging, drug delivery, magnetically mediated hyperthermia, etc. In this paper, we report the results of the experimental investigation of submicron YFeO garnet particles obtained in different sizes by solution combustion synthesis (SCS) using glycine organic fuel to discuss the interdependence of peculiarities of the crystal and magnetic structure and size's influence on its functional magnetothermal performance.

Association of gene polymorphisms with body weight changes in prediabetic patients.

Background: Recent research has demonstrated that Type 2 Diabetes (T2D) risk is influenced by a number of common polymorphisms, including MC4R rs17782313, PPARG rs1801282, and TCF7L2 rs7903146. Knowledge of the association between these single nucleotide polymorphisms (SNPs) and body weight changes in different forms of prediabetes treatment is still limited. The aim of this study was to investigate the association of polymorphisms within the MC4R, PPARG, and TCF7L2 genes on the risk of carbohydrate metabolism disorders and body composition changes in overweight or obese patients with early carbohydrate metabolism disorders.

Experimental Studies of the Effect of Extract on the State of Adaptive Capabilities of Rats under Chronic and General Exposure to Cold.

Currently, there is an objective need to create fortified food products that allow not only to provide the body with energy, but also to replenish the deficiency of essential nutrients. A generalization of the information published by Rospotrebnadzor and the Institute of Nutrition of the Russian Academy of Medical Sciences indicates a deficiency in the diet of Russians of vitamins C, group B and β-carotene and minerals, including calcium and iron, regardless of the season of the year. The identified deviations lead to a violation of the immune status, a decrease in the body's resistance to infections, and other unfavorable environmental factors, leading to an increase in the level of morbidity and a decrease in working capacity.

[Structural and functional features of peripheral vasculature in patients with glaucoma].

Purpose: To study the reactivity of the vascular endothelium and the elastic properties of the upper and lower extremities, and assess the vascular innervation effect of Cytoflavin in patients with stable and rapidly progressive primary open-angle glaucoma (POAG).

Material And Methods: The study included 67 patients with POAG (mean age 66.3±1.

[Comparative assessment of the phytoncidity of woody plants in the selection of species for landscaping: the possibility of use in sanatorium-and-spa practice].

The Purpose Of This Study: Is a comparative assessment of the phytoncidity of woody plants of different botanical families and genera and the selection of taxa with a pronounced, long-term, and universal antimicrobial effect for use in greening and landscape construction in sanatorium-resort practice.

Material And Methods: The objects of research were 167 species, hybrids, and intraspecific forms of woody plants from 25 botanical families and 16 genera. Evaluation of phytoncidity was carried out using the method of treating streak inoculation of microbial test cultures with volatile emissions of leaves; gram-positive bacteria (ATCC 25923), gram-negative bacteria (ATCC 25922) and yeast-like fungi (ATCC 10231).

[Possibilities of ultrasound methods in diagnostics of eyelid tumors].

Purpose: To determine the informative value of ultrasound biomicroscopy (UBM) with A-scan for assessment of qualitative and quantitative characteristics of eyelid tumors less than 5 mm in size.

Material And Methods: The study included 25 patients (25 eyes) with eyelid tumors less than 5 mm in size. In addition to standard ophthalmic examination, complex ultrasound diagnostics including B-scan, Color Doppler imaging and UBM with A-scan were performed.

[Bilateral occlusion of retinal vessels in Waldenstrom's disease (a case study)].

The article describes a clinical case of bilateral occlusion of retinal vessels in a patient with Waldenstrom's disease - a rare lymphoplasmocytic tumor of the bone marrow characterized by a complex of syndromes, among which the syndrome of blood hyperviscosity dominates. Comprehensive clinical, instrumental and laboratory examinations revealed that besides the syndrome of blood hyperviscosity the patient also had loci of cerebral ischemia (according to magnetic resonance imaging), ocular hypoperfusion with severe deficiency of retinal and choroidal blood flow (according to Doppler methods) indicating the presence of ocular ischemic syndrome. Since bilateral occlusion of retinal vessels without concomitant vascular and/or systemic pathology is rare, patients with such diagnosis should be referred to a hematologist.

Morphological Changes in the Retina Under Conditions of Experimental In Vivo Regional Ischemia/Reperfusion.

Two models of retinal ischemia/reperfusion were developed in an experiment on rats and structural changes in eye tissues in the early and late postischemic periods were studied. Ischemia/reperfusion was modeled by elevation of intraocular pressure to 110 mm Hg for 30 min with air injection into the anterior chamber of the eye with a special device or subconjunctival administration of 0.2 ml 4×10 M endothelin-1.

Study of Magnetic Properties of FeNi Nanostructures Using the Mössbauer Spectroscopy Method.

Hyperfine interactions of Fe nuclei in FeNi nanostructures synthesized in polymer ion-track membranes were studied by Mössbauer spectroscopy. The main part of obtained nanostructures was FeNi nanotubes with bcc structure for 0 ≤ x ≤ 40, and with fcc structure for 50 ≤ x ≤ 90. The length, outside diameter and wall thickness of nanotubes were 12 μm, 400 ± 10 nm and 120 ± 5 nm respectively.

[The prospective of using plant polyphenols as functional food ingredients].

In this review we briefly discuss the publications dedicated to experimental evaluation of hypoglycemic, hypolipidemic and antioxidant properties of different plant polyphenols. The stages of preclinical studies of their efficacy are presented: in silico studies with molecular docking methods and in vivo studies with the use of genetic and medicamental models of type 2 diabetes. The results of own studies present the substantiation of prospects of using the plant polyphenol extracts as functional food ingredients for diet therapy and treatment of patients with type 2 diabetes.

[Impact of antiangiogenic therapy on ocular blood flow and microcirculation in diabetic macular edema].

Unlabelled: Today, diabetic macular edema (DME) is still one of the main causes of vision loss in patients with diabetes.

Purpose: To identify changes in the ocular blood flow and microvascular network of the macular zone in patients with DME after antiangiogenic therapy.

Material And Methods: In the course of the study, 25 patients (50 eyes) with monolateral clinically significant DME aged 67.

Hypertension Management in Diabetes: 2018 Update.

Several guidelines and position statements are published to help clinicians manage hypertension in patients with diabetes. Although there is an unequivocal call to treat hypertension in diabetes, professional organizations and experts have differing opinions regarding the most optimal blood pressure targets and treatments to lower vascular risks in the diabetes population. The objective of this article is to summarize the most recent hypertension management guidelines with particular attention to the origins and evidence behind these recommendations.

[The First Russian Consensus on the Multilevel Abobotulinumtoxin A Injections in Spastic Forms of Cerebral Palsy].

Spasticity treatment is one of the key aspects of the contemporary cerebral palsy (CP) rehabilitation that influences on the effectiveness of other methods. The paper presents the first Russian document that unites the recommendations for the BTA treatment of CP and could be used as the guideline for the multilevel injections. The Russian consensus on the multilevel botulinum toxin A (BTA) treatment of spastic CP is based on the international data and the results of national studies.

Genetic diversity and genomic signatures of selection among cattle breeds from Siberia, eastern and northern Europe.

Domestication in the near eastern region had a major impact on the gene pool of humpless taurine cattle (Bos taurus). As a result of subsequent natural and artificial selection, hundreds of different breeds have evolved, displaying a broad range of phenotypic traits. Here, 10 Eurasian B.

[Clinical and anatomical features of congenital microphthalmia and anophthalmia in children and conservative methods of rehabilitation].

Aim: To develop a comprehensive classification system of distinctive clinical and anatomical features of congenital microphthalmia and anophthalmia in children and to specify indications, contraindications, and optimal timing of the primary and subsequent prosthetic treatment.

Material And Methods: A total of 70 patients with congenital micro- or anophthalmia aged from 1 month to 12 years were examined. Besides the routine ophthalmic examination, all patients underwent eye and orbit ultrasound (axial length measurement and B-scan), computed tomography of the orbits and skull, and immunological tests for infectious diseases (enzyme-linked immunosorbent assays).

Value of Structural and Hemodynamic Parameters for the Early Detection of Primary Open-Angle Glaucoma.

Purpose: To compare the diagnostic value of ocular blood flow parameters and choroidal thickness (CT) with standard structural parameters for early glaucoma detection.

Methods: A total of 32 patients with pre-perimetric glaucoma were compared with 30 age-matched normal subjects. The thickness of the ganglion cell complex (GCC), retinal nerve fiber layer (RNFL), and the choroid and foveal loss volume (FLV) were measured by means of optical coherence tomography (OCT).

[Assessing resveratrol effect on ocular blood flow in experiment].

Aim: To study the effect of resveratrol on ocular blood flow in vivo in healthy rats and those that underwent retinal ischemia/reperfusion.

Material And Methods: The experimental study was performed on 40 Wistar rats (40 eyes). For ocular blood flow evaluation, color Doppler imaging (CDI), power Doppler (PD), and pulsed-wave spectral Doppler ultrasonography were performed using the Voluson E8 Expert ultrasonic diagnostic system (GE Healthcare).

[Ocular blood flow and retinal electrogenesis in retinitis pigmentosa].

Aim: to investigate correlations between changes in ocular hemodynamics revealed by color Doppler flow mapping (CDFM) and pulsed-wave (PW) Doppler imaging, one the one hand, and electrical activity of the retina, on the other, in patients with early, moderate, and severe retinitis pigmentosa (RP).

Material And Methods: A total of 20 patients (40 eyes) aged from 16 to 40 years (28.4 ± 8.

PANCREATITIS IN PREGNANCY: CASE MANAGMENT.

The purpose of the review is to summarise the current data on chronic and acute pancreatitis with the goal to improve the diagnostics and treatment of women during pregnancy, which complicates differential diagnosis of hepatopancreatobiliary system pathology. The features of the incidence, etiology, parhogenesis and evaluation of the severity of the clinical manifestations of acute pancreatitis in pregnant women are given, It is emphasis that the most frequent its reason is the gallstones following by the biliary pancreatitis. The experience of use in pregnant patients imaging methods - endoscopic ultrasound, magnetic resonance cholangiopancrearography and endoscopic retrograde cholangiopancreatography, as well as treatments that include endoscopic sphincterotomy, stone extraction from the common bile duct and laparoscopic cholecystectomy.

CHOLESTASIS OF PREGNANCY.

The article presents data concerning the prevalence, clinical manifestations, methods of diagnostics, treatment and prevention of cholestasis of pregnancy, as well as the case management depending on the gestation and the cholestasis severity. A clinical case of a typical course of cholesrasis of pregnancy is presented.

[Promising source of micronutrients for specialized foods with modified carbohydrate profile: traditional medicine experience].

Worldwide experience of Traditional medicine (TM) has been successfully applied to the development of modern standardized herbal medicines. Mainly researchers are guided by local sources of medicinal plants and traditional medical systems. TM experience is also used in the search of plants considered as sources of biologically active substances (BAS) and food ingredients.