Development and Validation of a Real-Time Service Model for Noise Removal and Arrhythmia Classification Using Electrocardiogram Signals.

Arrhythmias range from mild nuisances to potentially fatal conditions, detectable through electrocardiograms (ECGs). With advancements in wearable technology, ECGs can now be monitored on-the-go, although these devices often capture noisy data, complicating accurate arrhythmia detection. This study aims to create a new deep learning model that utilizes generative adversarial networks (GANs) for effective noise removal and ResNet for precise arrhythmia classification from wearable ECG data.

Applications of deep learning methods in digital biomarker research using noninvasive sensing data.

Noninvasive digital biomarkers are critical elements in digital healthcare in terms of not only the ease of measurement but also their use of raw data. In recent years, deep learning methods have been put to use to analyze these diverse heterogeneous data; these methods include representation learning for feature extraction and supervised learning for the prediction of these biomarkers. We introduce clinical cases of digital biomarkers and various deep-learning methods applied according to each data type.

Metal-enhanced fluorescence in polymer composite films with Au@Ag@SiO nanoparticles and InP@ZnS quantum dots.

For white light-emitting diode (LED) applications, semiconductor quantum dots (QDs) have been widely utilized as efficient down-converters to change the blue color of the light source into different emission colors. Because QDs offer spectral tunability over the entire visible light range, as well as improved color purity, they have rapidly replaced conventional phosphor-based white LEDs. However, for the sustainable growth of QD-mediated LEDs, the amount of QDs required must be reduced by enhancing the color-conversion efficiency.

Short-range ordered photonic structures of lamellae-forming diblock copolymers for excitation-regulated fluorescence enhancement.

Photonic crystals can be represented by periodic nanostructures with alternating refractive indices, which create artificial stop bands with the appearance of colors. In this regard, nanodomains of block copolymers and the corresponding structural colors have been intensively studied in the past. However, the practical application of photonic crystals of block copolymers has been limited to a large degree because of the presence of large defects and grain boundaries in the nanodomains of block copolymers.

Switching off FRET in the hybrid assemblies of diblock copolymer micelles, quantum dots, and dyes by plasmonic nanoparticles.

Recently, it has been noticed that surface plasmon resonance of metal nanoparticles can alter the intrinsic properties of nearby fluorophores. Field enhancement and radiative decay engineering are major principles for understanding a number of experimental observations such as enhanced and quenched emission of fluorophores in the vicinity of metal nanoparticles. At the same time, there are apparent similarities between surface-plasmon-coupled fluorescence and fluorescence resonance energy transfer (FRET), as both are near-field through-space interactions.

Controlled light emission in spin-assisted layer-by-layer assemblies with fluorophores.

We report controlled light emissions from spin-assisted layer-by-layer (LbL) thin films containing a donor-acceptor pair of fluorescent dyes. Based on their spectral overlap, we selected rhodamine 123 (R123) and rhodamine B (RB) as the donor and acceptor, respectively. For the construction of multilayered thin films, a complex of each dye and poly(sodium 4-sulfonate) (PSS-R123 and PSS-RB) was prepared and then alternately spin coated with poly(allyamine hydrochloride) (PAH).

Controlled fluorescence resonance energy transfer between ZnO nanoparticles and fluorophores in layer-by-layer assemblies.

We controlled the fluorescence resonance energy transfer (FRET) between ZnO nanoparticles and rhodamine B (RB) within multilayered thin films prepared by the layer-by-layer (LbL) assembling method. Positively charged ZnO nanoparticles and RB-labeled poly(allyamine hydrochloride) (RB-PAH) were accurately incorporated into LbL assemblies of polyelectrolytes. The distance between ZnO nanoparticles and RB-PAH was adjusted by varying the number of layers of pure polyelectrolytes, leading to the controlled FRET from ZnO nanoparticles to RB-PAH.

Hetero-telechelic dye-labeled polymer for nanoparticle decoration.

The synthesis of poly(methyl methacrylate) (PMMA) exhibiting one fluorescent dye (Texas Red) and one methyl disulfide end group is described. It is shown that the latter end group enabled the exchange of both oleic amine on gold nanoparticles (AuNP) and of oleic acid on CdSe/ZnS quantum dots (QD), allowing for a phase transfer of both types of nanoparticles (NP) from hexane into dimethylformamide due to the solubility provided by the PMMA chains. For AuNP, a fluorescence quenching of the dye was found due to fluorescence resonance energy transfer (FRET) from the dye to the AuNP, while QDs caused a fluorescence enhancement by FRET from the QD to the attached dyes.