Adenovirus vaccines, particularly the COVID-19 Ad5-nCoV adenovirus vaccine, have emerged as promising tools in the fight against infectious diseases. In this study, we investigated the structure of the T cell response to the Spike protein of the SARS-CoV-2 virus used in the COVID-19 Ad5-nCoV adenoviral vaccine in a phase 3 clinical trial (NCT04540419). In 69 participants, we collected peripheral blood samples at four time points after vaccination or placebo injection.
View Article and Find Full Text PDFMultiple quantum (MQ) dynamics was investigated in quasi-one-dimensional H zigzag spin chains in hambergite (BeBOOH) single crystals. Due to the non-linear arrangement of the spins, dipolar coupling strengths alternate along the chain. To solve the problem of MQ NMR experiments taking too much time due to extremely long H spin-lattice relaxation times, the samples were exposed to gamma irradiation to produce the defects accelerating the relaxation.
View Article and Find Full Text PDFHerein, we show that thin films of MAPbI, FAPbI, (CsMA)PbI, and (CsMAFA)PbI, where MA and FA are methylammonium and formamidinium cations, respectively, tolerate ultrahigh doses of γ rays approaching 10 MGy without significant changes in their absorption spectra. However, among the studied materials, FAPbI was the only one that did not form metallic lead due to its extreme radiation hardness. Infrared near-field optical microscopy revealed the radiation-induced depletion of organic cations from the grains of MAPbI and their accumulation at the grain boundaries, whereas FAPbI on the contrary lost FA cations from the grain boundaries.
View Article and Find Full Text PDFT cells play a pivotal role in reducing disease severity during SARS-CoV-2 infection and formation of long-term immune memory. We studied 50 COVID-19 convalescent patients and found that T cell response was induced more frequently and persisted longer than circulating antibodies. We identified 756 clonotypes specific to nine CD8+ T cell epitopes.
View Article and Find Full Text PDFCellulose was produced by the modified traditional method with 35% yield from the stem of Sosnovsky hogweed and was characterized by elemental analysis, infrared (IR) spectroscopy, powder X-ray diffractometry, differential scanning calorimetry (DSC) and X-ray photoelectron spectroscopy (XPS). For , the degree of crystallinity (approximately 70%) and the glass transition temperature (105-108 °C) were determined. It was found that the whiteness characteristic in the case of was 92% and this significate was obtained without a bleaching procedure using chlorine-containing reagents.
View Article and Find Full Text PDFBy means of X-ray computed microtomography (XCMT), the existence of a developed porous structure with an average pore diameter of ~3.5 μm and pore content of ~1.1 vol.
View Article and Find Full Text PDFUnderstanding the hallmarks of the immune response to SARS-CoV-2 is critical for fighting the COVID-19 pandemic. We assessed antibody and T cell reactivity in convalescent COVID-19 patients and healthy donors sampled both prior to and during the pandemic. Healthy donors examined during the pandemic exhibited increased numbers of SARS-CoV-2-specific T cells, but no humoral response.
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