The ANKK1/DRD2 gene TaqIA polymorphism (rs1800497) is associated with the severity of extrapyramidal side effects of haloperidol treatment in CYP2D6 extensive metabolizers with schizophrenia spectrum disorders.

Objectives: Extrapyramidal symptoms (EPS) are one of the most prominent side effects of haloperidol. Variability of EPS severity may be associated with the genetic factors, affecting both haloperidol pharmacokinetics (e.g.

Comprehensive Clinical and Social Research at the Moscow Research Institute of Psychiatry: Translation into Clinical Practice.

The article is devoted to the work of the Moscow Research Institute of Psychiatry to improve psychiatric care for patients with psychotic disorders. An important feature of this work was an integrated approach, in which the clinical picture of the disease was assessed in close connection with the patient's personal and psychological characteristics, social conditions of his life, therapeutic opportunities, rehabilitation potential and organizational structure of care. The article reflects the results of many years of work of the department of outpatient psychiatry and the organization of psychiatric care under the guidance of Professor I.

Cognitive bias salience in patients with schizophrenia in relation to social functioning: A four-case observation study.

Neurocognition and social cognition are the core deficits influencing social outcomes in patients with schizophrenia. These deficits are present in the prodromal phase, throughout the illness and in first-degree relatives. They are considered in the framework of neurodevelopmental or neurodegenerative models as well as candidates for endophenotypes of schizophrenia.

Multidrug-Resistant Tuberculosis Treatment Outcomes in Relation to Treatment and Initial Versus Acquired Second-Line Drug Resistance.

Background: Resistance to second-line drugs develops during treatment of multidrug-resistant (MDR) tuberculosis, but the impact on treatment outcome has not been determined.

Methods: Patients with MDR tuberculosis starting second-line drug treatment were enrolled in a prospective cohort study. Sputum cultures were analyzed at a central reference laboratory.

Annual risk of tuberculous infection measured using serial skin testing, Orel Oblast, Russia, 1991-2005.

Objective: To compare trends in direct annual risk of tuberculous infection (ARTI) during 1991-2005 in relation to tuberculosis (TB) incidence and to indirect estimates of ARTI derived from the prevalence of tuberculin skin test (TST) positivity in schoolchildren in Orel Oblast, Russia.

Design: In 2005, we abstracted annual TST results and vaccination histories from a representative sample of schoolchildren in Orel Oblast, Russia, where bacille Calmette-Guerin (BCG) vaccination and annual TST of children are nearly universal. We calculated direct ARTI based on the percentage of children tested with TST conversions each year, excluding conversions following BCG vaccination.

Extensive drug resistance acquired during treatment of multidrug-resistant tuberculosis.

Background: Increasing access to drugs for the treatment of multidrug-resistant (MDR) tuberculosis is crucial but could lead to increasing resistance to these same drugs. In 2000, the international Green Light Committee (GLC) initiative began to increase access while attempting to prevent acquired resistance.

Methods: To assess the GLC's impact, we followed adults with pulmonary MDR tuberculosis from the start to the end of treatment with monthly sputum cultures, drug susceptibility testing, and genotyping.

[Depressive symptoms diagnosis and treatment of schizophrenia and schizophrenia spectrum disorders in Russian clinical practice].

A cohort study of depression in schizophrenia and schizophrenia spectrum disorders was conducted in four Russian regional mental health services with the use of simultaneous one-day census on October 20, 2011. The total number of patients in this study was 1269: 753 patients were receiving outpatient treatment, 143 patients were served in day clinics and 373 patients were in-patients in psychiatric hospitals. Depressive symptoms were present in 6.

Outcomes and follow-up of patients treated for multidrug-resistant tuberculosis in Orel, Russia, 2002-2005.

Setting: Multidrug-resistant tuberculosis (MDR-TB) treatment facility, Orel Oblast, Russian Federation.

Objectives: To determine factors associated with poor outcome and to document status of patients after recording of TB outcomes.

Design: Retrospective review of prospective single cohort.

Prevalence of extensively drug-resistant tuberculosis in Vladimir and Orel regions, Russia.

Setting: Joint World Health Organization (WHO) projects in Vladimir and Orel regions, Russia.

Objective: To study the prevalence of extensively drug-resistant (XDR) tuberculosis (TB).

Methods: Drug susceptibility testing of second-line drugs (ofloxacin, kanamycin, capreomycin, ethionamide, cycloserine and para-aminosalicylic acid) was performed on isolates from multidrug-resistant TB cases from 1 January to 31 December 2006.

Experimental study of the pharmacokinetics of a tryptophan-containing dipeptide GB-115.

Pharmacokinetics of an original compound GB-115 (N-phenylhexanoylglycyltryptophan) synthesized on the basis of the structure of endogenous tetrapeptide cholecystokinin-4 was studied by means of high-performance liquid chromatography. Pharmacokinetic parameters were calculated after intravenous and peroral administration of GB-115. Our results indicate that this dipeptide is resistant to peptidases.

Encouraging outcomes in the first year of a TB control demonstration program: Orel Oblast, Russia.

Setting: Orel, Russia.

Objective: To evaluate outcomes of tuberculosis (TB) patients treated in the first year of a TB control demonstration project using a revised strategy of directly observed treatment, short-course (DOTS). Standard methods recommended by World Health Organization (WHO) were adapted to include mycobacterial cultures.

Inactivation of simian rotavirus SA 11 by hydrogen peroxide.

The kinetics and extent of the simian rotavirus SA 11 (RV) inactivation by low concentrations of hydrogen peroxide (HP) were determined. The curves illustrating the kinetics of crude virus inactivation have "tailing off". The inactivation of the purified virus runs according to the first-order kinetics.