Optimization and Assessment of Three Generation Solid Dispersion for Enhancement of Solubility and Dissolution for Montelukast Sodium.

Objective: To enhance the solubility of Montelukast sodium using three generation polymers by solid dispersion method.

Material And Method: Montelukast sodium with selected generation of carriers were used for phase solubility and to optimize the stoichiometric ratio for the preparation of SD with MS. Various characterization techniques (FTIR, DSC and XRD) have been used to evaluate the MS-SD formulations with selected hydrophilic carriers.