Antimicrobial resistance burden in India and Germany in 2022: A systematic analysis along with One Health perspective.

Globally increasing antibiotic resistance has been linked to the extensive use of antibiotics in medical, veterinary, and agricultural Practices. This study aims to investigate the correlations of antimicrobial-resistant of various pathogens in three compartments: humans, animals and the environment in India and Germany. A systematic search was carried out in Medline via PubMed, Google Scholar, and science direct, including studies published in 2022.

Enhanced drug delivery with nanocarriers: a comprehensive review of recent advances in breast cancer detection and treatment.

Breast cancer (BC) remains a leading cause of morbidity and mortality among women worldwide, with triple-negative breast cancer (TNBC) posing significant treatment challenges due to its aggressive phenotype and resistance to conventional therapies. Recent advancements in nanocarrier technology offer promising solutions for enhancing drug delivery, improving bioavailability, and increasing drug accumulation at tumor sites through targeted approaches. This review delves into the latest innovations in BC detection and treatment, highlighting the role of nanocarriers like polymeric micelles, liposomes, and magnetic nanoparticles in overcoming the limitations of traditional therapies.

Zn-MOF@rGO nanocomposite: a versatile tool for highly selective and sensitive detection of Pb and Cu ions in water.

In this work, a hybrid nanocomposite material (PUC2@rGO) was prepared by integrating our previously developed Zn-MOF (PUC2) with reduced graphene oxide (rGO) through the wet impregnation method. The characterization of PUC2@rGO was performed using various analytical techniques, including FTIR, PXRD, FE-SEM, HR-TEM, XPS, zeta potential, and time-resolved FL spectroscopy. Our investigation primarily focused on assessing the composite's capability to detect water pollutants.

Phytoconstituents of Nymphaea rubra flowers and their anti-diabetic metabolic targets.

Nymphaea rubra (N. rubra) flowers are prevalent in subtropical regions for both dietary and traditional medicinal purposes, attributing to their beneficial properties in supporting overall health. This study first time provides descriptions of the antidiabetic and dyslipidemic properties employing STZ induced high fat diet fed diabetic rats and inhibition of α-amylase enzyme activity first by in vitro analyses, followed by a confirmatory in silico study to create a stronger biochemical rationale.

Nano-therapeutics: The upcoming nanomedicine to treat cancer.

Nanotechnology is considered a successful approach for cancer diagnosis and treatment. Preferentially, cancer cell recognition and drug targeting via nano-delivery system include the penetration of anticancer agents into the cell membrane to damage the cancer cell by protein modification, DNA oxidation, or mitochondrial dysfunction. The past research on nano-delivery systems and their target has proven the beneficial achievement in a malignant tumor.

Vitamin D supplementation modulates glycated hemoglobin (HBA1c) in diabetes mellitus.

Diabetes is a metabolic illness that increases protein glycosylation in hyperglycemic conditions, which can have an impact on almost every organ system in the body. The role of vitamin D in the etiology of diabetes under RAGE (receptor for advanced glycation end products) stress has recently received some attention on a global scale. Vitamin D's other skeletal benefits have generated a great deal of research.