Publications by authors named "Kirsty J L Wark"
Article Synopsis
- Resident memory T cells (T-RMs) play a key role in providing immunity in epithelial barrier tissues but can also lead to chronic inflammatory disorders, especially in the skin, where they are known as resident cutaneous memory T cells (cT-RMs).
- This review highlights cT-RMs as central contributors to various chronic skin conditions like psoriasis and atopic dermatitis, emphasizing their ability to create an immune memory that may trigger disease flare-ups.
- The article also discusses current and potential treatments that may influence cT-RMs' development and survival, identifying the need for further research to improve long-term management of chronic skin diseases.
Introduction: Hidradenitis suppurativa (HS) is a chronic autoinflammatory skin disease. It is characterised by the development of abscesses and nodules in intertriginous anatomical sites. Whilst it is now recognised as an autoinflammatory condition rather than an infective disease, bacteria are implicated in disease pathogenesis.
View Article and Find Full Text PDFZosteriform cutaneous metastases are an unusual and rare morphological variant. We discuss the case of a 78-year-old gentleman with a background of end-stage renal disease with metastatic adenocarcinoma of the lung which was diagnosed due to the development of zosteriform cutaneous metastases around his vascular catheter (vascath) site. The vascath may have acted as a traumatic nidus for lymphatic spread.
View Article and Find Full Text PDF