Publications by authors named "Kirsten Rydell"
Daptomycin (DAP) is often used as a first-line therapy to treat vancomycin-resistant infections, but emergence of DAP non-susceptibility threatens the effectiveness of this antibiotic. Moreover, current methods to determine DAP minimum inhibitory concentrations (MICs) have poor reproducibility and accuracy. In enterococci, DAP resistance is mediated by the LiaFSR cell membrane stress response system, and deletion of encoding the response regulator results in hypersusceptibility to DAP and antimicrobial peptides.
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- * The study focuses on the LiaFSR system in enterococci, revealing that LiaX acts as a sentinel molecule that recognizes DAP and regulates the cell membrane response, although its function in certain strains is less understood.
- * An optimized LiaX ELISA was developed to evaluate 86 clinical bloodstream infection isolates, finding that elevated LiaX levels correlate with DAP resistance, even in some strains that test susceptible by standard methods, suggesting a need to
Article Synopsis
- The study highlights the growing concern over carbapenem-resistant Pseudomonas aeruginosa (CR-PA) and its resistance patterns over time.
- Significant increases in non-susceptibility to crucial antibiotics like ceftolozane/tazobactam were observed, rising from 2% to 17% between past (1999-2005) and more recent (2017-2018) isolates.
- The presence of carbapenemase and extended-spectrum beta-lactamase (ESBL) genes among contemporary strains indicates a worrying trend in antibiotic resistance that may complicate treatment options.
Background: Ceftolozane/tazobactam is a β-lactam/β-lactamase inhibitor combination with activity against a variety of Gram-negative bacteria, including MDR . This agent is approved for hospital-acquired and ventilator-associated bacterial pneumonia. However, most real-world outcome data come from small observational cohorts.
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- In the U.S., resistance to vancomycin in enterococci is uncommon, but this study identified three cases of ST6 vancomycin-resistant Enterococcus faecalis causing infections (bacteremia) in different patients and locations.* -
- The specific isolates were obtained between 2018 and 2020 from Miami, FL, and Houston, TX, indicating a possible trend in resistance emergence in these areas.* -
- The isolates contained a gene cluster within a transposon that suggests multiple introductions into the ST6 E. faecalis strain over time.*
Characteristics of community-acquired carbapenem-resistant Enterobacterales.
J Antimicrob Chemother
September 2022
Background: Community-acquired carbapenem-resistant Enterobacterales (CA-CRE) are an important threat.
Methods: In CRACKLE-2, we defined patients with CA-CRE as admitted from home, without pre-existing conditions, and a positive culture within 48 h of admission. Healthcare-associated CRE (HA-CRE) were those with the lowest likelihood of community acquisition, not admitted from home and cultured >48 h after admission.
Carbapenem-resistant Klebsiella pneumoniae (CR) is an urgent public health threat. Worldwide dissemination of CR has been largely attributed to clonal group (CG) 258. However, recent evidence indicates the global emergence of a CR CG307 lineage.
View Article and Find Full Text PDFCarbapenem-resistant Acinetobacter baumannii (CR) is a major cause of health care-associated infections. CR is typically multidrug resistant, and infection is difficult to treat. Despite the urgent threat that CR poses, few systematic studies of CR clinical and molecular epidemiology have been conducted.
View Article and Find Full Text PDFBackground: Vancomycin-resistant enterococci (VRE) are major therapeutic challenges. Prospective contemporary data characterizing the clinical and molecular epidemiology of VRE bloodstream infections (BSIs) are lacking.
Methods: The Vancomycin-Resistant Enterococcal BSI Outcomes Study (VENOUS I) is a prospective observational cohort of adult patients with enterococcal BSI in 11 US hospitals.