Incremental value of high-sensitivity cardiac troponin T for risk prediction in patients with suspected acute myocardial infarction.

Background: High-sensitivity cardiac troponin assays have better analytical precision and sensitivity than earlier-generation assays when measuring cardiac troponin at low concentrations. We evaluated whether use of a high-sensitivity assay could further improve risk stratification compared with a standard cardiac troponin assay.

Methods: We enrolled consecutive patients presenting with acute chest pain, 30% of whom were diagnosed with acute coronary syndrome.

Impact of soluble fms-like tyrosine kinase-1 and placental growth factor serum levels for risk stratification and early diagnosis in patients with suspected acute myocardial infarction.

Aims: Angiogenic factors play an important role in the development of atherosclerosis and show pronounced changes during acute myocardial infarction (AMI). We analysed the impact of placental growth factor (PlGF) and its endogen opponent, soluble fms-like tyrosine kinase-1 (sFlt-1), on clinical outcome and the early diagnosis of AMI.

Methods And Results: This multicentre study enrolled patients presenting with symptoms suggestive of AMI.