Publications by authors named "Kirsten G M Aspros"
Estrogen-regulated miRs in bone enhance osteoblast differentiation and matrix mineralization.
Mol Ther Nucleic Acids
September 2023
Estrogen signaling is critical for the development and maintenance of healthy bone, and age-related decline in estrogen levels contributes to the development of post-menopausal osteoporosis. Most bones consist of a dense cortical shell and an internal mesh-like network of trabecular bone that respond differently to internal and external cues such as hormonal signaling. To date, no study has assessed the transcriptomic differences that occur specifically in cortical and trabecular bone compartments in response to hormonal changes.
View Article and Find Full Text PDFArticle Synopsis
- Triple negative breast cancer (TNBC) is a highly aggressive form of breast cancer, making it essential to understand its biology and develop new treatments.
- Estrogen receptor beta (ERβ), found in about 20% of TNBC tumors, acts as a tumor suppressor and is linked to better patient outcomes by inhibiting growth-promoting genes.
- Research using modified TNBC cells shows that when ERβ can't bind DNA, it loses its ability to regulate key genes and suppress cancer cell growth, highlighting how ERβ's DNA interaction is crucial for its cancer-fighting properties.
Triple Negative Breast Cancer (TNBC) accounts for 15-20% of all breast cancer cases, yet is responsible for a disproportionately high percentage of breast cancer mortalities. Thus, there is an urgent need to identify novel biomarkers and therapeutic targets based on the molecular events driving TNBC pathobiology. Estrogen receptor beta (ERβ) is known to elicit anti-cancer effects in TNBC, however its mechanisms of action remain elusive.
View Article and Find Full Text PDFPurpose: Significant controversy exists regarding the expression patterns of estrogen receptor beta (ERβ) in normal and diseased breast tissue. To address this issue, we have validated two ERβ antibodies, optimized the IHC protocols for both antibodies and now report the expression patterns of ERβ in normal and malignant breast tissues.
Methods: ERβ antibody specificity was determined using western blot and IHC analysis.