Publications by authors named "Kirsten Falch"
We compared lesion-based sensitivity of dual-time-point FDG-PET/CT, bone scintigraphy (BS), and low-dose CT (LDCT) for detection of various types of bone metastases in patients with metastatic breast cancer. Prospectively, we included 18 patients with recurrent breast cancer who underwent dual-time-point FDG-PET/CT with LDCT and BS within a median time interval of three days. A total of 488 bone lesions were detected on any of the modalities and were categorized by the LDCT into osteolytic, osteosclerotic, mixed morphologic, and CT-negative lesions.
View Article and Find Full Text PDFThe purpose was to investigate the interrater agreement of FDG-PET/CT and bone scintigraphy for diagnosing bone recurrence in breast cancer patients. A total of 100 women with suspected recurrence of breast cancer underwent planar whole-body bone scintigraphy with [99mTc]DPD and FDG-PET/CT. Scans were evaluated independently by experienced nuclear medicine physicians and the results for one modality were blinded to the other.
View Article and Find Full Text PDFArticle Synopsis
- Delayed-time-point imaging with 18F-FDG-PET/CT can help differentiate between malignant and benign breast cancer lesions, particularly in cases with low metabolism.
- Imaging at 1 hour and 3 hours post-FDG injection revealed a significant increase in standardized uptake values (SUVmax) for malignant lesions, with the largest increases observed in lung and lymph node metastases.
- After correcting for partial volume effects, SUVmean significantly improved, especially in breast lesions, highlighting the importance of time-point imaging and correction methods in accurately assessing breast cancer recurrence.
Purpose: To prospectively investigate the diagnostic accuracy of [(18)F]fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography (CT) with dual-time-point imaging, contrast-enhanced CT (ceCT), and bone scintigraphy (BS) in patients with suspected breast cancer recurrence.
Patients And Methods: One hundred women with suspected recurrence of breast cancer underwent 1-hour and 3-hour FDG-PET/CT, ceCT, and BS within approximately 10 days. The study was powered to estimate the precision of the individual imaging tests.