Lived Experience of Patients and Caregivers in Rare Genetic Neurological Gene Therapy Clinical Trials in Children.

To date, sparse attention has been paid to the importance of the "lived experience" of participants and their caregivers in pediatric gene therapy (GT) trials for rare genetic neurological disorders. Pediatric GT studies differ meaningfully from adult GT studies as the decision to participate involves a dyad: the child participant and their caregiver(s). As a multistakeholder group of authors, we are a diverse group with expert perspectives on the social, emotional, physical, and logistical burdens/benefits of trial participation and the myriad ways they affect pediatric GT research.

Forgotten peatlands of eastern Australia: An unaccounted carbon capture and storage system.

In a carbon-constrained world, global peatlands are vital carbon capture and storage systems. Here we calculate regional carbon stocks, sequestration rates and potential carbon emissions of Temperate Highland Peat Swamps on Sandstone (THPSS) found in low order headwater streams in eastern Australia. We find that total carbon stocks within THPSS in two regions are 25 Mt CO eq.

Geomorphic controls on fluvial carbon exports and emissions from upland swamps in eastern Australia.

Temperate Highland Peat Swamps on Sandstone (THPSS) are upland wetlands, similar to fens in the Northern Hemisphere and are found at the headwaters of low-order streams on the plateaus of Eastern Australia. They are classified as endangered ecological communities under State and National legislation. Previous works have identified particular geomorphic characteristics that are important to carbon storage in these low energy sediment accumulation zones.