[Diagnosis and treatment of inflammatory infiltrates of the abdominal cavity in Crohn disease].

An infiltrate in the abdominal cavity in Crohn's disease does not hinder successful drug therapy in most cases. A positive effect (regression or a marked decrease in the size of the infiltrate) is achieved in 80% of patients, mostly in those with a moderately or mildly severe form of the disease in which a sufficiently prolonged, 10-12-week course of antiinflammatory treatment can be conducted. Combination of prednisolone with azathioprine and antibiotics is most justified.

[Theopek absorption efficiency in chronic diseases of the large intestine].

A total of 10 patients with chronic ulcerative colitis (CUC) were examined. The patients took a single dose of theopec (300 mg). The patients with chronic obstructive lung diseases (COLD) without intestinal disorders served as controls.

[The pharmacokinetic characteristics of theophylline in patients with chronic nonspecific intestinal diseases in relation to its routes of administration into the gastrointestinal tract].

Theophylline pharmacokinetics was investigated upon introduction of euphylline (0.15 g) at four levels of gastrointestinal tract: orally (20 patients), into the jejunum (15 patients) at enterogastroduodenoscopy, in the ileocecal area (8 patients) at colonoscopy and rectally (9 patients). Absorption speed depended on the variant of the gastrointestinal introduction rather than on the variant of chronic nonspecific intestinal disease, and appeared maximal in the drug introduction into the jejunum.

[Evaluation of blood loss volume and the degree of activity of nonspecific ulcerative colitis by using Cr51-labeled erythrocytes].

The volume of daily blood loss was studied in 47 patients with nonspecific ulcerative colitis by labelling red cells with radioactive sodium chromate. The volume of blood loss correlated closely with the activity of the inflammatory process evaluated during colonoscopy. Unlike visual, often erroneous, evaluation of blood loss, radioisotope study in dynamics makes it possible to objectify the appraisal of the activity and severity of the process, choose a rational therapeutic tactics, and determine the efficacy of the antiinflammatory treatment.

[Prevention of postoperative suppurative complications in patients with inflammatory diseases of the large intestine].

The results of surgical treatment of 103 patients with inflammatory diseases of the colon were analysed. An unfavourable outcome was noted in presence before the operation of the disease complications, and deep metabolic disorders as well. A decrease in the level of serum albumins and hematocrit, increase in the leukocytic count and seromucoid level were prognostically informative.

[Status of the pituitary-adrenal system in patients with non- specific ulcerative colitis].

The blood content of basal cortisol was studied in 54 patients with a total form of non-specific ulcerous colitis and in 23 of them that of ACTH. A low cortisol level was revealed in 71.4 per cent of the patients, while the level of ACTH remained unchanged.

[IgG, IgM, IgA, secretory IgA and the complement components C3, C4 and C9 in the large intestine in nonspecific ulcerative colitis and Crohn disease].

The immunohistological study of the large intestines excised from 20 patients with ulcerous colitis and Crohn's disease was made with the use of the indirect immunofluorescence test. A considerable increase in the number of IgG immunocytes has been noted in the lamina propria of the mucous membrane, especially in infiltrations around ulcers. In cases of a highly active inflammatory process accompanied by the pronounced destruction of the epithelium, IgG and C3, C4, C9 were detected in the epithelium of crypts and in blood vessels of the mucous membrane and the submucosa.

[Bran in the treatment of irritable bowel syndrome].

The paper deals with the problem of using wheat bran in the treatment of patients with irritable colon syndrome expressed as spastic constipation. The effectiveness of the treatment with the wheat bran only (in a dose of 30-35 g/day), and in combination with drugs was comparatively studied in 105 patients. The bran fractions differing in the particle size, in the content of cellulose, starch and vitamins were used in the treatment.

Efficiency of hemosorption in treatment of patients with ulcerative colitis.

One hundred and seven sessions of hemosorption were performed on 77 patients with severe ulcerative colitis. Clinically, improvement was demonstrated in the reduction of the signs of intoxication in 50 to 60 per cent of patients. Combination of hemosorption and anti-inflammatory medication allowed to achieve a remission or a marked improvement determined by clinical observation or endoscopy of 39 from 52 patients with a severe, total form of the disease, whereas toxic influence of sulfasalazine was controlled and extra-intestinal complications were weakened in 8 patients from 11.

[Effect of human immunoglobulins on microflora of the large intestine in nonspecific ulcerative colitis].

The use of commercial preparations of human immunoglobulin for the treatment of ulcerous colitis produces a positive effect on the microflora of the large intestine, contributing to the disappearance of Proteus, the lactose-negative forms of enterobacteria and the hemolytic variants of staphylococci, as well as to the increase of the amount of useful indigenous microflora (bifidobacteria and lactobacteria). The quantitative and qualitative improvement of the microflora leads, possibly, to the decrease of the intoxication of the body, improvement in the activity of the intestine and increased vitamin formation, thus giving a pronounced clinical effect and improvement in the endoscopic picture of the mucous membrane of the large intestine, peculiar for this disease.