A scoping review of literature on clozapine from former USSR states published in Russian language.

Objective: Access to literature on clozapine in Russian language remains strikingly limited. We aimed to identify and translate clinical evidence on clozapine-based treatment outcomes.

Methods: We performed a systematic review in PubMed, Embase and scientific indexes from former USSR states searching for articles published in Russian from the database inception till January 2023 and summarized the data in a scoping review (PROSPERO Reg.

An international guideline with six personalised titration schedules for preventing myocarditis and pneumonia associated with clozapine.

White blood cell (WBC) monitoring has reduced clozapine-treated patient deaths associated with agranulocytosis to a rarity. However, clozapine protocols and package inserts worldwide provide no instructions for preventing myocarditis or pneumonia during clozapine titrations. Prescribers worldwide are largely unaware of that.

[Assessment of drug therapy in psychiatric elderly patients based on the AGS Beers criteria.].

The study objective was to analyze the frequency of prescription of potentially inappropriate medications (PIMs) to elderly patients treated in a psychiatric in-patient setting. This study was carried out using AGS Beers criteria, an anti-polypharmacy tool developed under the auspices of the American Geriatric Association. The study indicates a high frequency of use of PIMs from the following pharmacological groups: benzodiazepine derivatives, non-steroidal anti-inflammatory drugs (long-term use), as well as drugs with significant anticholinergic potential.

[Safety of psychopharmacotherapy: a clinical and pharmacological approach].

The prescription of psychotropic drugs requires a thorough assessment not only of the effectiveness of pharmacotherapy, but also of its safety. It is an essential component of the rational treatment of patients with mental disorders. Most of adverse drug reactions are predictable and, accordingly, preventable.

[The drug-drug interactions in a psychiatric hospital].

An analysis of 132 drugs used in a psychiatric hospital for the estimation of the possibility of drug-drug interactions has been carried out. It has been established that one in five potential combination has a drug-drug interaction with clinically significant interactions being more frequent. Psychotropic drugs occupy a leading position in the number of such interactions.

Monitoring drug safety in Astrakhan, Russia.

Background: The problem of drug safety will never disappear as new drugs are delivered in increasing numbers. They have high biological activity and adverse drug reactions (ADR) [1]. Currently, adverse drug reactions are the fourth leading cause of death for patients.

[Clinical laboratory diagnosis of neonatal hepatic failure].

The paper provides the results of diagnosing hepatic failure in 102 neonatal infants with various diseases. Based on clinical, routine biochemical, instrumental, and morphological studies, the author proposes a clinical classification of the grades of neonatal hepatic failure. A close correlation (Pierson coefficient) has been statistically found between the severity of neonatal hepatic failure with respective clinical and laboratory criteria.