Publications by authors named "Kirill Y Kostyunin"
The causative agent of the new coronavirus infection SARS-CoV-2 has unique properties causing hyperinflammatory syndrome and cytokine storm, as well as widespread endotheliitis and thrombotic microangiopathy, initially detected in the lungs of adult patients who died from a severe form of the disease. Venous and arterial thrombosis in adults were identified as common causes of severe complications and deaths in new coronavirus infections. There are very few reports of thrombotic events in children with COVID-19 in the literature.
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- This study investigates cases of vasculitis in children linked to COVID-19, highlighting a limited but concerning phenomenon.
- Four pediatric cases showed diverse systemic involvement, primarily affecting the skin; while all patients presented with high inflammatory markers, none fully met criteria for multisystem inflammatory syndrome.
- Treatment included systemic glucocorticosteroids, with additional therapies like DMARDs and biologics, underscoring the potential severity of COVID-19-related vasculitis and the need for more comprehensive research.