Publications by authors named "Kirill Lyapichev"
Primary gastric T-cell lymphomas (PGTL) are exceedingly rare with an estimated incidence of 0.0091 per 100,000 person-years, affecting mainly elderly males. PGTL can present with a variety of gastrointestinal symptoms, but patients only rarely present with perforation.
View Article and Find Full Text PDFArticle Synopsis
- Gelatinous bone marrow transformation (GBMT) is a rare medical condition involving the atrophy of fat cells and the buildup of a gelatinous substance in the bone marrow, leading to decreased blood cell production (hypoplastic hematopoiesis).
- A study reviewed bone marrow specimens from patients with a BMI of <18.5, revealing that 30% of those evaluated had GBMT associated with ring sideroblasts, a specific type of abnormal red blood cell.
- Notably, one patient’s ring sideroblasts were linked to copper deficiency, highlighting that GBMT may be misdiagnosed as myelodysplastic syndrome without further investigation.
Primary central nervous system (CNS) diffuse large B-cell lymphoma with MYC and BCL2 rearrangements is a very rare lymphoma subtype. Deep brain stimulation is an effective minimally invasive therapeutic option for the treatment of refractory movement disorders, as well as some psychiatric disorders and chronic pain syndromes. Herein, we report a case of CNS lymphoma, which developed around an electrode of a deep brain stimulation (DBS) device.
View Article and Find Full Text PDFArticle Synopsis
- Breast implant-associated anaplastic large cell lymphoma is classified as a distinct type of cancer linked to textured breast implants, prompting new challenges for medical professionals handling patients with these devices.
- While much focus has been on this more serious lymphoma, benign issues related to breast implants also affect 20-30% of patients, necessitating careful assessment.
- The review discusses a variety of benign complications, detailing their clinical presentations and imaging features, and outlines a structured method for diagnosing and managing breast implant-related specimens.
From the archives of MD Anderson Cancer Center: Plasmablastic lymphoma presenting as a kidney mass in an immunocompetent patient: Case report and literature review.
Rachelle Gietzen Vidarshi Muthukumarana Peeyush Bhargava Dmitrii Vozniuk Beenu Thakral Kirill A Lyapichev
Ann Diagn Pathol
December 2023
Article Synopsis
- Plasmablastic lymphoma (PBL) is a rare, aggressive form of lymphoma often seen in immunocompromised individuals, particularly those with HIV or EBV, and usually presents in the oral cavity.
- The reported case involves a 65-year-old man without HIV or EBV who presented with significant abdominal issues and was found to have a large kidney mass diagnosed as PBL, after undergoing various tests and treatments.
- This case is notable because it highlights how PBL can occur in immunocompetent patients and emphasizes the need for more research to improve its diagnosis, especially distinguishing it from similar conditions like plasma cell myeloma.
Article Synopsis
- * Metastatic tumors, particularly neuroendocrine tumors in the spleen, are uncommon and often under-reported in medical literature.
- * A case study highlighted that flow cytometry on FNA samples can effectively identify neuroendocrine tumors in the spleen, allowing for quicker and more accurate diagnosis despite the challenges of sample size.
Primary bone lymphoma (PBL) is a rare extranodal presentation within lymphomas and primary bone malignancies. Pathologic fracture (PF) is a common complication of metastatic bone disease but is, rarely, the presentation of a primary bone tumor. We report a case of an 83-year-old man with a history of untreated prostate cancer, presenting with atraumatic fracture of his left femur after months of intermittent pains and weight loss.
View Article and Find Full Text PDFArticle Synopsis
- The study analyzed 142 patients diagnosed with Richter transformation of diffuse large B-cell lymphoma (RT-DLBCL), focusing on morphological, immunophenotypic, and molecular characteristics.
- Findings revealed that RT-DLBCL predominantly exhibited immunoblastic morphology with specific marker expressions, including high levels of CD19 and BCL2, while a significant portion displayed a non-germinal center B-cell immunophenotype.
- Genetic analysis indicated notable chromosome alterations and common mutations involving TP53, with no significant difference in overall survival between different immunophenotypes, although CD5 expression appeared to correlate with overall survival outcomes.
Article Synopsis
- Primary splenic diffuse large B-cell lymphoma (PS-DLBCL) is a rare type of lymphoma that primarily affects the spleen and can sometimes mimic an abscess.
- A 62-year-old patient showed symptoms such as flank pain and abdominal swelling, leading to the discovery of an 8-cm splenic mass diagnosed through imaging.
- Microscopic examination of the mass revealed atypical large cells and high proliferation rates, with unusual CD30 positivity, raising questions about its classification compared to classic Hodgkin lymphoma.
Article Synopsis
- - Peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS) is a rare and aggressive form of T-cell lymphoma that doesn't fit into established categories and primarily affects lymph nodes, but can involve other organs.
- - Leukaemic presentations of PTCL, NOS are extremely uncommon, with no documented cases of isolated leukemic presentations found in existing literature.
- - This text introduces a case study of a patient with PTCL, NOS who exhibited a leukemic presentation, highlighting its rarity in medical documentation.
Article Synopsis
- Digital pathology enhances the field of diagnostics by allowing remote work for pathologists, improving diagnostic quality, and streamlining business processes, especially highlighted during the COVID-19 pandemic.
- The article shares insights from Russia's first fully digital pathomorphological laboratory, UNIM, covering various aspects such as technology use, economic benefits, and integration with laboratory information systems.
- Comprehensive analysis of statistical data and survey results on doctors' perspectives will be presented, showcasing the cost-effectiveness and competitiveness of the digital platform in the healthcare market.
Article Synopsis
- The 2021 WHO Classification of Thoracic Tumours categorizes thymomas based on their cell structure, with benign types labeled as A, AB, B1, B2, and B3, while malignant forms are referred to as thymic carcinoma.
- Although thymomas have the potential to be malignant, cases of them spreading outside the chest (extra-thoracic metastasis) are extremely rare, with only 39 such instances documented since 1999.
- The report details a unique case of a type B1 thymoma with a single liver metastasis that occurred seven years after the initial tumor was removed, highlighting its relationship with the autoimmune condition myasthenia gravis and discussing the prognosis and classification of thymomas
Article Synopsis
- - Chronic myeloid leukemia (CML) is a type of blood cancer where there is an overproduction of myeloid cells, often linked to the Philadelphia chromosome, which is present in 90-95% of cases.
- - The Philadelphia chromosome results from a specific genetic translocation that increases kinase activity, which contributes to the disease's development, and some cases also involve more complex chromosomal rearrangements.
- - A unique case of a three-way translocation variant was found in a 40-year-old woman, leading to symptoms like visual changes and high white blood cell counts, confirmed by specific genetic testing techniques.
Article Synopsis
- Primary bone lymphoma, particularly Primary Non Hodgkin Lymphoma of the bone, is a rare condition that tends to have a favorable prognosis, with diffuse large B-cell lymphoma being the most common subtype, often presenting as painful masses in unusual locations like the mandible.
- A case study of a 45-year-old male revealed multi-step diagnostic procedures, including a fine needle aspiration that identified atypical lymphoid cells, leading to a diagnosis of PB-NHL and successful treatment through chemotherapy.
- The study culminated in a review of 42 cases, proposing improved diagnostic approaches for clinicians, emphasizing the importance of fine needle aspiration and flow cytometry in achieving timely diagnoses to enhance patient care.
Article Synopsis
- PGK1 is an enzyme crucial for producing ATP in glycolysis, and mutations in its gene can lead to conditions like hemolytic anemia, CNS dysfunction, and myopathy.
- A novel mutation known as "Galveston" was identified in a 4-year-old boy displaying all three clinical problems.
- The study highlights unique hematopathology and neuroimaging findings, emphasizing the diagnostic challenges for doctors and contributing to the understanding and management of this condition.