Publications by authors named "Kirill A Novoselov"
Apurinic/apyrimidinic (AP) sites are endogenous DNA lesions widespread in human cells. Having no nucleobases, they are noncoding and promutagenic. AP site repair is generally initiated through strand incision by AP endonuclease 1 (APE1).
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- Somatic mutations in the promoter region of the human telomerase reverse transcriptase gene are common in cancer, with the presence of G-quadruplex (G4) structures linked to higher mutagenicity and genome instability.
- A bioinformatics analysis of 141 mammalian species revealed that G4 motifs are mostly found near the transcription start site and are prevalent on the non-coding strand, with a notable portion being evolutionarily conserved.
- Additionally, a significant increase in nucleotide substitutions was observed in conserved G4 motifs compared to surrounding genomic regions, suggesting that G4s may hinder DNA repair and influence evolutionary adaptations.