[Vasomotor Endothelial Function in Healthy Individuals: Contact Types of Character].

We studied the vascular endothelial vasomotor function in healthy young individuals, depending on the type of character accentuation, levels of neuroticism, depression and anxiety. It is shown that the types of character accentuation effect on endothelial vasomotor function in healthy men and women. Personality characteristics of a person can be a significant risk factor for disease, the pathogenesis of which is the starting element of endothelial vasomotor dysfunction.

Effect of continuous irradiation with terahertz electromagnetic waves of the NO frequency range on behavioral reactions of male albino rats under stress conditions.

We studied the effect of terahertz waves (NO frequency range, 150.176-150.664 GHz) on stress-induced variations in behavioral reactions of male albino rats during hypokinetic stress.

[Microcirculation in the injured spleen by different operations in children].

43 children were operated on spleen injury: 14 were splenectomized; 29 splenectomy were completed with partial spleen tissue autotransplantation into the omentum. Changes of homeostatic system, hemoreology and immune status were followed up within 1 year after the operation, Connections between the type of the operation performed and the listed above changes were followed.

[Changes in the immune status of patients operated for splenic lesions in the late postoperative period and their relation to the development of complications].

This analysis of changes in the immune status of patients operated for splenic lesions is based on the observations of 126 subjects. Fifty of them underwent autolientransplantation and 26 conservative surgery. The main parameters of humoral and cellular immunity were measured along with changes in the microflora.

Effects of terahertz radiation at atmospheric oxygen frequency of 129 GHz on blood nitrite concentrations under conditions of different types of stress against the background of administration of nonselective inhibitor of constitutive NO-synthases.

We studied the effect of terahertz radiation at atmospheric oxygen frequency 129 GHz on blood nitrite concentration in different types of experimental stress against the background of administration of nonselective inhibitor of constitutive NO-synthases. Normalizing effects of radiation on blood nitrite dynamics in animals with acute stress was shown after 15-min exposure and in animals with chronic stress after 30-min exposure. No positive effect of terahertz radiation was observed on altered blood nitrite concentration in male rats after preliminary administration of nonselective constitutive NO-synthase isoform inhibitor L-NAME.

Correction of microcirculatory disturbances with terahertz electromagnetic radiation at nitric oxide frequencies in albino rats under conditions of acute stress.

Terahertz electromagnetic irradiation at frequencies corresponding to NO molecular emission and absorption spectrum 150.176-150.664 GHz corrects disturbances in peripheral circulation typical of acute stress reaction in rats during acute immobilization stress.

[Changes gas and electrolyte structure of blood under influence terahertz radiations on frequencies nitrogen oxide 150,176-150,664 GHz in the conditions of stress].

Influence terahertz radiations nitrogen oxide frequencies of 150,176 - 150,664 GHz on gas and electrolyte structure of blood of white rats being in condition of sharp stress. It is shown that at 15 minute mode of influence terahertz waves on frequencies nitrogen oxide observe partial restoration of studied indicators gas and electrolyte structure of blood at stress animals. At 30 minute mode of influence the specified waves observe complete recovery of the broken indicators gas and electrolyte blood structure.

[Evaluation of the course of an infectious process by erythrocyte membrane permeability].

The physical and chemical parameters of red blood cells were studied in patients with urinary tract infection. The permeability parameters were proposed to study erythrocyte membrane permeability. Complete recovery of the latter in patients with somatic diseases due to antibacterial therapy was found to suggest that the preservation of erythrocyte dysfunction.

Peculiarities of the effect of terahertz radiation at nitric oxide frequencies on gaseous and electrolyte composition of the blood in different types of stress.

We studied the effect of terahertz radiation at NO frequencies 150.176-150.664 GHz on gaseous and electrolyte composition of the blood in albino rats during stress.

Automated analysis of antidepressants' effect in the forced swim test.

The forced swim test (FST) is a commonly used procedure of preclinical screening of drugs for the antidepressant activity. It has high predictive validity for a large group of antidepressant drugs blocking serotonin and noradrenaline reuptakes and improvement of immobility time evaluation in the FST is an important problem of preclinical psychopharmacology. Here a new automated version of the FST was developed.

[Use of terahertz electromagnetic radiation at nitric oxide frequencies for the correction of thyroid functional state during stress].

The influence of terahertz electromagnetic radiation at nitric oxide frequencies (150.176-150.664 Ghz) on the functional activity of rat thyroid gland subjected to acute immobilization stress has been studied.

Effect of high power terahertz irradiation on platelet aggregation and behavioral reactions of albino rats.

Intensive terahertz irradiation at the nitric oxide emission and absorption spectrum frequencies (150.176-150.664 GHz) applied for 60 min to male albino rats subjected to acute immobilization stress enhanced platelet aggregation and induced signs of depression.

Role of cholinergic and cytokine regulation of T cell function in stimulation and inhibition of immune reactions in intoxication by organophosphorus compounds in different doses.

Experiments on outbred albino rats showed that administration of acetylcholine and aceclidine in a dose of 0.1 LD50 for 3 days and of dimethyl dichlorovinyl phosphate (organophosphorus compound) in a single dose of 0.05 LD50 stimulated the function of Th1 and Th2 lymphocytes and cytokine production by these cells.

[Reduction of the immune responses and synthesis of cytokines associated with Th1 and Th2 lymphocyte function and their correction by polyoxidonium under conditions of subacute intoxication by organophosphorus compounds].

Experiments on Wistar rats showed that subacute poisoning by organophosphorus compounds dimethyldichlorovinyl phosphate (DDVF), malation, and dimethylparation (total dose, 1.0 LD50) suppresses both cell and humoral immune responses and significantly decreases the level of blood cytokines (IFNg, IL-4) and the IFNg/IL-4 ratio in comparison to the control, which is evidence for a greater lesion of Th1 cells in comparison to Th2 cells. The immunomodulator polyoxidonium administered for four days in a daily dose of 700 microg/kg under conditions of subacute intoxication with organophosphorus compounds restores the cell and humoral immune responses and the synthesis of cytokines.

Effects of terahertz irradiation at nitric oxide frequencies on intensity of lipoperoxidation and antioxidant properties of the blood under stress conditions.

The effects of terahertz irradiation at the nitric oxide frequencies (150.176-150.664 GHz) on the intensity of lipoperoxidation and antioxidant properties of the blood were examined on albino rats subjected to immobilization stress.

[Aggregative ability of thrombocytes and their receptor apparatus at a distant period after different operations on the injured spleen].

The aggregative ability of thrombocytes and the composition of the carbohydrate component of the thrombocyte glycoprotein receptors were studied in 126 patients after operations on the injured spleen within the terms of more than one year. It was found that organ-sparing operations and autolientransplantation in the injured spleen did not influence the changes of the thrombocyte aggregative properties at a remote postoperative period. Splenectomy results in an increased aggregative ability of thrombocytes at the expense of increased number of glycoprotein receptors containing D-mannose, N-acetyl-D-glucosamines, D-galactose, N-acetyl-D-glucosamines, N- acetylneuraminic acid and D-galactose.

Changes in the cytokine profile and reduced function of lymphocyte subpopulations in subacute tetrachloromethane poisoning.

Experiments on outbred albino rats showed that subacute poisoning with tetrachloromethane in a total dose of 1.0 LD50 appreciably decreased blood concentrations of cytokines (IFN-gamma, IL-2, IL-4, IL-6, IL-10), reduced the IFN-gamma/IL-4 ratio in comparison with the control, and suppressed the immune reactions, which attests to greater damage to Th1 compared to Th2 lymphocytes.

[Psychophysiological characteristics of patients with arterial hypertension under different social conditions].

The aim of the study was to compare psycho-physiological personality characteristics of patients with newly diagnosed arterial hypertension serving sentence in corrective-labour institutions and treated in a city hospital. In the first group, 36 men of the 612 had grade 1 or 2 essential arterial hypertension. Analysis of psycho-physiological characteristics showed that emotive behaviour and anxiety are the major personality traits hampering compensation of intrapsychic conflict of the psychosomatic type and promote neurotization and depression in subjects with arterial hypertension serving sentence in corrective-labour institutions.

[Penitentiary microenvironment as a risk factor of psychosomatic health (digest)].

This analytical survey shows that health status of jail prisoners in Russia as worldwide is strikingly different from that of the general population. The difference is accounted for by the concentration of socially dysadapted individuals in penitentiary institutions, conditions and relations facilitating the spread of certain infections in prisons. This problem is of importance for society at large because most prisoners sooner or later come back to the normal life and influence national health statistics.

[Nitric oxide microcirculatory unit of hemostasis system].

Nitric oxide plays a dominant role in regulation of different cells, tissues, organs and system in the body including cardiovascular system. Take into consideration a major role of microcirculatory disorders in pathogenesis of various illnesses in this review take up the role of nitric oxide in microcirculatory regulation, especially of it intravascular component, witch functioning depends from the functions of microcirculatory unit of hemostasis system.

Use of terahertz electromagnetic radiation for correction of blood rheology parameters in patients with unstable angina under conditions of treatment with isoket, an NO donor.

The effect of terahertz electromagnetic radiation at the emission and absorption frequencies of NO molecular spectrum on blood rheology were studied in vitro in patients with unstable angina treated with isoket (NO donor). Irradiated NO donor isoket produced better normalizing effect on blood viscosity and erythrocyte deformability in patients with unstable angina.

[Changes in cortikosteron concentration--a marker of stress-response under the influence of terahertz radiations at nitrogen oxide frequencies of 150, 176-150, 664 GHz].

Influence of electromagnetic radiation ofterahertz frequencies of molecular spectrum of radiation and absorption oxide nitrogen of 150, 176-150, 664 GHz by means of device KVCH-NO forming specified spectra, on concentration at stress-realizing hormone cortikosteron in conditions of sharp and chronic stress was is studied. It is shown that preliminary continuous 15-minute influence by electromagnetic radiation of terahertz range at frequencies of oxide nitrogen 150, 176-150, 664 GHz limits development of stress-reaction due to reduction of allocation by a of adrenal glands of glucocorticoids, in particular cortikosteron, that led restriction of excessive activation of stress-realizing system. The given fact serves as the proof of stress-limiting function of electromagnetic radiation at the given range.

[Specific changes of the thrombocyte aggregation function in acute pancreatitis].

On the basis of investigations of thrombocyte aggregation in 126 patients with acute pancreatitis it was shown that independent of the severity of the pancreatitis the aggregation function of thrombocytes decreased. The effective treatment resulted in its normalization not earlier than within 15 days.

[The hemostasis system indices after operations of spleen trauma].

The authors have studied changes of the hemostasis system in 85 patients operated on the traumatized spleen, followed up from 1 through 15 years after operation. It was established that organ-saving operations and autolientransplantation fail to result in substantial changes in indices of the hemostasis system, while after spleenectomy there were pronounced shifts.