Radiomodulating Properties of Superparamagnetic Iron Oxide Nanoparticle (SPION) Agent Ferumoxytol on Human Monocytes: Implications for MRI-Guided Liver Radiotherapy.

Superparamagnetic iron oxide nanoparticles (SPION) have attracted great attention not only for therapeutic applications but also as an alternative magnetic resonance imaging (MRI) contrast agent that helps visualize liver tumors during MRI-guided stereotactic body radiotherapy (SBRT). SPION can provide functional imaging of liver parenchyma based upon its uptake by the hepatic resident macrophages or Kupffer cells with a relative enhancement of malignant tumors that lack Kupffer cells. However, the radiomodulating properties of SPION on liver macrophages are not known.

[Hybrid reconstructions in patients with lower limb chronic ischaemia and multilevel arterial lesions].

Presented herein is a review of the literature related to performing hybrid operations for multilevel lesions of the arteries of the lower limbs. This is accompanied and followed by analysing the data on variants of stagewise use of different methods of revascularization in hybrid interventions ("open" and endovascular) on the lower extremities, as well as complications, lethality rates, and remote results as compared with the parallel parameters obtained while performing non-hybrid operations.

The TB Portals: an Open-Access, Web-Based Platform for Global Drug-Resistant-Tuberculosis Data Sharing and Analysis.

The TB Portals program is an international consortium of physicians, radiologists, and microbiologists from countries with a heavy burden of drug-resistant tuberculosis working with data scientists and information technology professionals. Together, we have built the TB Portals, a repository of socioeconomic/geographic, clinical, laboratory, radiological, and genomic data from patient cases of drug-resistant tuberculosis backed by shareable, physical samples. Currently, there are 1,299 total cases from five country sites (Azerbaijan, Belarus, Moldova, Georgia, and Romania), 976 (75.

Consequences and countermeasures in a nuclear power accident: Chernobyl experience.

Despite the tragic accidents in Fukushima and Chernobyl, the nuclear power industry will continue to contribute to the production of electric energy worldwide until there are efficient and sustainable alternative sources of energy. The Chernobyl nuclear accident, which occurred 26 years ago in the former Soviet Union, released an immense amount of radioactivity over vast territories of Belarus, Ukraine, and the Russian Federation, extending into northern Europe, and became the most severe accident in the history of the nuclear industry. This disaster was a result of numerous factors including inadequate nuclear power plant design, human errors, and violation of safety measures.

[Cytogenetic study of an interspecific hybrid Helianthus praecox x H. annuus, its parental forms and two backcrosses].

Meiosis of wild species (H. praecox) and cultivated sunflower (H. annuus), their F1 interspecific hybrid as well as two backcross generations has been studied.

[Study of inheritance of morphological traits in sunflower. 1. Genetic control of sunflower flower pigmentation, branchiness and restoration of pollen fertility].

The inheritance of sunflower flowers color has been investigated in inbred lines collection of Yurjev Plant Production Institute. It has been shown, that in F1 occurs yellow color only being most found among all the types of flowers' coloration. The 3: 1 and 9 : 3 : 4 types of segregation ratios have been revealed in F2 that is indicative of difference parents by one and two genes, respectively.

[Analysis of linkage between genes controlling enzymes in sunflower].

The polymorphism of leucine aminopeptidase in 23 inbred lines of sunflower of mutant origin was studied. The isozyme spectrum of leucine aminopeptidase is presented as a single zone of enzyme activity controlled by one gene. This gene was shown to be inherited independently from genes of esterase and 6-phosphogluconate dehydrogenase.

[Polymorphism and genetic control of some isozyme systems in mutant sunflower lines].

Polymorphism of six isozyme systems (ME, EST, 6-PGD, AAT, ACP, IDH) of sunflower mutant inbred lines has been studied. It was shown that only three of them were polymorphic (ME, EST, 6-PGD). Two isoforms were observed for each polymorphic enzymic zone.

[Genotype peculiarities of crossability of cultivated sunflower with wild species and the use of embryo culture in interspecific hybridization].

Peculiarities of the genotype effect of cultivated and wild sunflower species on crossability indices and in vitro hybrid embryonic development have been investigated. It was shown that selection of initial material can considerably influence seed-setting and in vitro embryonic development in the cross group of cultivated sunflower with annual and perennial wild species. The range of plant hybrids obtained through somatic embryogenesis and induction of adventitious shoots was higher in comparison with direct growth of embryos in in vitro culture.

[Studying genetic diversity in inbred sunflower lines by RAPD and isoenzyme analyses].

Genetic diversity of 30 inbred sunflower lines was examined by RAPD and isozyme analyses. The inbred lines were shown to be highly polymorphic by RAPD markers. The line distribution on genetic similarity dendrograms based on the RAPD and isozyme data was analyzed.

Proteinaceous complexes from mitochondrial contact sites.

A Triton X-100 extract from rat brain mitochondria was obtained using low detergent/protein ratio. From this extract a proteinaceous complex was purified; its molecular weight was as high as 880 kD. The complex contained both hexokinase and creatine kinase activity.

[Device for removing concrements from tubular organs].

Wide use of Dormia's loop for removing the concrements from tubular organs led to development of numerous designs of this device. Search for new designs serves one purpose: decrease the traumatism and risk of injury to the organ during the procedure. The new design is characterized by a longer length of service and is more reliable.

Reducing maternal mortality in St Petersburg.

Following the entry of St Petersburg into Europe's Healthy Cities Project in 1991 it was decided that the highest priority should be given to reducing the city's maternal mortality ratio, then standing at approximately 70 deaths per 100,000 live births. Preventing deaths from unsafe, illegal abortion became the main focus of attention. The use of modern contraceptive methods was promoted, information was disseminated to improve the utilization of family planning services, special outreach services for teenagers were established, and providers were given opportunities for education and training.

[The diagnosis and treatment of postvagotomy disorders].

From experience with various types of vagotomy in 3,102 patients and study of the late-term results, it was established that recurrent ulcer developed in 4.7%, dysphagia in 2.9%, incompetence of the esophagogastric junction in 9.

[Use of the hormonal preparation prephyson in the treatment of epilepsy in children and adolescents].

Children and adolescents suffering from epilepsy were treated with anticonvulsants and prephyson. The paroxysmal and psychopathological symptomatology showed positive changes, more remarkable as compared to those seen as a result of administering anticonvulsants alone, accompanied by the improvement of endocrine system function. The characteristic features of the clinical symptomatology and course of epilepsy requiring the use of hormonal drugs were defined.

[Basal secretion of hormones of the anterior lobe of the pituitary gland, thyroid gland and adrenal cortex in children and adolescents with epilepsy].

The article presents the results of measuring the anterior hypophysis lobe, thyroid and adrenocortical hormones basal secretion in epileptic children and adolescents measured during the anticonvulsant therapy. The peculiarities of functional state of endocrine glands in epileptic patients were compared to those in healthy adolescents and children. Analyzed was their dependence on the nature, course and clinical manifestations of the disease, the course and efficiency of anticonvulsant therapy.

[Basal levels of thyroxine, somatotropin and cortisol in children with epilepsy].

The results of radioimmunoassay for basal levels of total thyroxin, somatotropin, and cortisol in the blood serum of epileptic children are presented. Basal levels of total thyroxin and somatotropin were significantly reduced. A decrease in hormone concentrations was more pronounced in an unfavourable versus favourable course of the disease.