Comparison of Two Different Alfaxalone Concentrations Combined with Midazolam to Anesthetize Cynomolgus Macaques () for Plethysmography.

Plethysmography is employed in nonhuman primates (NHPs) to calculate respiratory minute volume and determine the exposure time required to deliver an aerosol at the target dose. Anesthetic drugs can impact breathing parameters like steady-state minute volume (SSMV) central to aerosol dosing. Alfaxalone-midazolam mixtures (AM) provide superior parameters for plethysmography in cynomolgus macaques.

Comparison of the anesthetic efficacy and cardiopulmonary effects of continuous rate infusions of alfaxalone-2-hydroxypropyl-beta-cyclodextrin and propofol in dogs.

Objective: To compare the cardiopulmonary effects of continuous rate infusions (CRIs) of alfaxalone-2-hydroxypropyl-beta-cyclodextrin (HPCD) and propofol in healthy dogs.

Animals: 6 young adult medium-sized healthy crossbred dogs.

Procedures: A crossover design was used with a washout period of 6 days between anesthetic treatments.

Comparative bioavailability of fluoxetine after transdermal and oral administration to healthy cats.

Objective: To determine bioavailability, pharmacokinetics, and safety for transdermal (TD) and oral administration of fluoxetine hydrochloride to healthy cats.

Animals: 12 healthy mixed-breed sexually intact 1- to 4-year-old purpose-bred cats.

Procedure: A single-dose pharmacokinetic study involving 3 groups of 4 cats each was conducted in parallel.