Ochronotic Arthropathy of the Shoulder - A Rare Case Report.

Introduction: Alkaptonuria is a metabolic disorder due to accumulation of homogentisic acid, leading to destruction of major joints. Very few cases of ochronosis with shoulder involvement have been reported in literature.

Case Report: We report a 31-year-old male who presented with shoulder pain for 4 months.

Can trauma scores predict the length of hospital stay of patients with fractures after earthquake-related blunt injury?

Objective: The number of patients during disastrous conditions was high, and triage is essential. In chaotic circumstances, orthopedic surgeons can also struggle with patient selection, not only for surgical selection but also for the necessity of hospitalization. So, the performance of the Injury Severity Score, New Injury Severity Score, and Trauma and Injury Severity Score was compared in victims who were struck under the wreckage and had fractures due to the Kahramanmaras Earthquake.

8-Anilino-1-naphthalenesulfonate-Conjugated Carbon-Coated Ferrite Nanodots for Fluoromagnetic Imaging, Smart Drug Delivery, and Biomolecular Sensing.

Background: Superparamagnetic properties and excitation independence have been incorporated into carbon-decorated manganese ferrite nanodots (MnFe@C) to introduce an economical and safer multimodal agent for use in both T1-T2 MRI and fluorescence-based imaging to replace the conventional highly toxic heavy metal contrast agents.

Methods: The surface conjugation of 8-anilino-1-naphthalenesulfonate (ANS) to MnFe@C nanodots (ANS-MnFe@C) enhances both longitudinal and transverse MRI relaxation, improves fluorescence for optical imaging, and increases protein detection sensitivity, showing higher multimodal efficacy in terms of molar relaxivity, radiant efficiencies, and fluorescence sensitivity compared to MnFe@C.

Results: The band gap energy was determined using Tauc's equation to be 3.

Enhanced behavioral impact of optimized bupropion-encapsulated bilosomes over traditional niosomes treating depression.

Bupropion (Bpn), an FDA-approved NDRI (norepinephrine-dopamine reuptake inhibitor), poses risks of seizures and liver failure due to its stimulant properties, necessitating the development of alternative formulations. This research aims to develop a Bpn nanoformulation within bilosomal vesicles to enhance therapeutic efficacy at lower doses, using three bile salts, span 20 surfactants, and cholesterol via thin-film hydration. Optimization of bilosomal stability is achieved by trialing various ingredient concentrations, identifying a surfactant-to-cholesterol-to-bile salt ratio of 1.

Cardiac MRI in Duchenne and Becker Muscular Dystrophy.

Background And Objectives: Cardiovascular magnetic resonance imaging (CMRI) is the noninvasive technique of choice for early detection of cardiac involvement in Duchenne and Becker muscular dystrophy (DMD and BMD, respectively), but is seldom used in routine clinical practice in the Indian context. We sought to determine the prevalence of CMRI abnormalities in patients with DMD and BMD and to compare the CMRI parameters with the phenotypic and genotypic characteristics.

Methods: A prospective, observational study was conducted on patients genetically diagnosed with DMD and BMD who could complete CMRI between March 2020 and March 2022.

Information engine with feedback delay based on a two-level system.

An information engine based on a two-level system in contact with a thermal reservoir is studied analytically. The model incorporates delay time between the measurement of the state of the system and the feedback. The engine efficiency and work extracted per cycle are studied as a function of delay time and energy spacing between the two levels.

Qualitative and Quantitative Electrocardiogram Parameters in a Large Cohort of Children with Duchenne Muscle Dystrophy in Comparison with Age-Matched Healthy Subjects: A Study from South India.

Background: Electrocardiography (ECG) remains an excellent screening tool for cardiac assessment in Duchenne muscular dystrophy (DMD), but an accurate interpretation requires comparison with age-matched healthy controls.

Objective: We examined various ECG parameters in children with DMD, in comparison with age-matched controls.

Methods: Standard 12-lead ECG tracings of serial patients were screened for quality and selected.

Surgical outcomes of common arterial trunk repair beyond infancy.

Background: The aim of this study is to analyze the clinical outcomes of common arterial trunk repair beyond infancy in terms of both early- and long-term outcomes.

Methods: Between January 2003 and December 2019, 56 patients underwent repair for common arterial trunk beyond infancy at our institute. Median age was 34.

A Case Report Of "Synovial Chondromatosis Of Elbow" Treated With Synovectomy.

Introduction: Synovial chondromatosis is a rare non- malignant bone tumor. Most commonly middle aged people are affected . This condition most commonly occurs in knee joints, and rarely, it may occur in other joints.

Validated HPLC-UV method for quantification of paxalisib, a pan PI3K and mTOR inhibitor in mouse plasma: Application to a pharmacokinetic study in mice.

Paxalisib is a pan-PI3K and mTOR inhibitor, currently entering into Phase II clinical trials as a potential drug to treat glioblastoma patients. We report the development and validation of a high-performance liquid chromatography (HPLC) method for the quantitation of paxalisib in mouse plasma as per the US Food and Drug Administration regulatory guidelines. From the mouse plasma, paxalisib and the internal standard (IS; filgotinib) were extracted using ethyl acetate as an extraction solvent.

Driven particle in a one-dimensional periodic potential with feedback control: Efficiency and power optimization.

A Brownian particle moving in a staircaselike potential with feedback control offers a way to implement Maxwell's demon. An experimental demonstration of such a system using sinusoidal periodic potential carried out by Toyabe et al. [Nat.

Validated LC-MS/MS method for the determination of copanlisib in mouse dried blood spots.

Copanlisib is a dual PI3K-δ inhibitor, used in follicular lymphoma treatment. In this research, we report a validated LC-MS/MS method for quantifying copanlisib from a mouse dried blood spot (DBS). We validated the method in line with the guidelines of the US Food and Drug Administration.

PET-MRI in idiopathic inflammatory myositis: a comparative study of clinical and immunological markers with imaging findings.

Background: We sought to determine the utility of PET-MRI in diagnosing Idiopathic Inflammatory Myositis (IIM), and look for association between FDG uptake and clinical, pathological and laboratory parameters.

Methods: A retrospective, observational study was conducted on IIM patients having positive serum autoantibodies and who underwent PET-MRI (3-Tesla SIEMENS Biograph MR scanner) between 2017 and 2021. Thirty patients who underwent PET-MRI to detect systemic metastasis without muscle involvement formed the control group.

Validated liquid chromatography-tandem mass spectrometry method for simultaneous quantitation of bendamustine and copanlisib in mouse plasma: Application to a pharmacokinetic study in mice.

In this study, we report the development and validation of an LC-tandem mass spectrometry method for the simultaneous quantitation of bendamustine and copanlisib in mouse plasma as per the US FDA regulatory guidelines. The sample processing involves extraction of bendamustine and copanlisib along with internal standard (IS; warfarin) from 50 μL mouse plasma using a liquid-liquid extraction method. The chromatographic separation of bendamustine, copanlisib and the IS was achieved on an Atlantis dC column using an isocratic mobile phase (5 mM ammonium acetate:methanol, 20:80 v/v).

Surgical Management of Aortopulmonary Window and its Associated Cardiac Lesions.

The aim of this study was to review our institutional experience with patients who underwent surgical repair of aortopulmonary window, either as an isolated lesion or in association with other cardiac anomalies. Between January 2006 and December 2020, 183 patients underwent surgical repair of aortopulmonary window at our institute. Sixty-three patients had associated lesions (Group 1); 120 patients had isolated aortopulmonary window (Group 2).

Phantom Assessment of an Image-free Ultrasound Technology for Online Local Pulse Wave Velocity Measurement.

Cardiovascular community has started clinically adopting the assessment of local stiffness, contrary to the traditionally measured carotid-femoral pulse wave velocity (PWV). Though they offer higher reliability, ultrasound methods require advanced hardware and processing methods to perform real-time measurement of local PWV. This work presents a system and method to perform online PWV measurement in an automated manner.

High-Framerate A-Mode Ultrasound for Vascular Structural Assessments: In-Vivo Validation in a Porcine Model.

Capturing vascular dynamics using ultrasound at a high framerate provided a unique way to track time-dependent and transient physiologic events non-invasively. In this work, we present an A-model high-framerate (500 frames per second) image-free ultrasound system for monitoring vascular structural and material properties. It was developed based on our clinically validated ARTSENS technology.

Gaussian-Mixture Modelling of A-Mode Radiofrequency Scans for the Measurement of Arterial Wall Thickness.

Measurement of arterial wall thickness is an integral component of vascular properties and health assessment. State-of-the-art automated or semi-automated techniques are majorly applicable to B-mode images and are not available for entry-level in-expensive devices. Considering this, we have earlier developed and validated an image-free (A-mode) ultrasound device, ARTSENS for the evaluation of vascular properties.

Efficiency estimation for an equilibrium version of the Maxwell refrigerator.

Maxwell refrigerator as a device that can transfer heat from a cold to hot temperature reservoir making use of information reservoir was introduced by Mandal et al. [Phys. Rev.

Spontaneous Umbilical Cord Hematoma.

Spontaneous umbilical cord hematoma is a rare complication with a usually benign course but is potentially fatal without vigilant and timely medical intervention. We present the case of a 23-year-old primigravida mother who presented in labor. She was placed on continuous fetal heart rate monitoring, which showed two episodes of fetal heart rate tracing of the category II variety.

Clinically relevant variants in a large cohort of Indian patients with Marfan syndrome and related disorders identified by next-generation sequencing.

Marfan syndrome and related disorders are a group of heritable connective tissue disorders and share many clinical features that involve cardiovascular, skeletal, craniofacial, ocular, and cutaneous abnormalities. The majority of affected individuals have aortopathies associated with early mortality and morbidity. Implementation of targeted gene panel next-generation sequencing in these individuals is a powerful tool to obtain a genetic diagnosis.