Reversible inhibition of sperm under guidance as an intratubular and reversible contraception in female rats: An experimental study.

Background: Reversible inhibition of sperm under guidance ("RISUGⓇ") is a promising intravasal male contraceptive.

Objective: An exploratory study was conducted with a concept of non-invasive, transcervical, single-intervention and reversible contraception using RISUGⓇ in females.

Materials And Methods: In this experimental study, 60 adult Wistar albino female rats weighing 150-155 g, 3-4 months old were divided into four groups: group I: sham-operated control; group II: tubal occlusion with RISUG for 90 days; group III: tubal occlusion with RISUGⓇ for 90 days and reversal with dimethyl sulphoxide and group IV: tubal occlusion with RISUGⓇ for 90 days and reversal with 5% NaHCO.