Publications by authors named "Kiran S Patil"
Article Synopsis
- Poor dissolution of axitinib (AXT) limits its oral effectiveness, prompting a study on liquisolid technology to enhance its dissolution rate and bioavailability for treating renal cell carcinoma.
- LS compacts were created using specific materials, and various analyses (P-XRD, DSC, SEM) confirmed the transformation of crystalline AXT to a more soluble form, leading to significant improvements in drug dissolution and bioavailability.
- The optimal LS formulation showed a notable increase in drug release (over 99% vs. 18.05% for traditional tablets) and exhibited enhanced cytotoxic effects against cancer cells, suggesting a promising low-cost treatment option for patients.
A recyclable protocol using a CeO-nanorod catalyst for borylation of alkyl halides with Bpin (pin = OCMeCMeO) is reported. A wide range of synthetically useful alkyl boronate esters are readily obtained from primary and secondary alkyl electrophiles, including unactivated alkyl chlorides, demonstrating broad utility and functional group tolerance. Preliminary investigation revealed an involvement of in situ formed catalytically active boryl species.
View Article and Find Full Text PDFBackground And Aim: Several patient-related factors have been identified which are responsible for the development of rotator cuff tears. The purpose of the study was to assess various parameters which can be risk factors for the development of supraspinatus tendon tear.
Methods: A total of 100 patients with symptomatic rotator cuff tear, aged > 18 years, of either gender, presenting to the outpatient department were included in this cross-sectional study.
Simultaneous Bilateral Femoral Neck Stress Fracture in a Young Stone Mason.
Case Rep Orthop
June 2015
Unilateral stress fractures of the femoral neck are very uncommon and bilateral involvement is even rarer. They commonly occur in athletes, military recruits, older persons, or individuals with underlying metabolic disorders and very seldom in normal individuals. We present a rare case of simultaneous bilateral fracture neck of femur in a 25-year-old man who came with complaints of pain in bilateral groin for 1 month.
View Article and Find Full Text PDFIntroduction: Osteoblastoma is a rare (incidence <1%) benign locally aggressive osteoblastic lesion of bone with rare malignant transformation. Benign osteoblastoma is the term used by Jaffe to denote an uncommon neoplasm of bone characterized by vascular osteoid and bone forming matrix rich in osteoblasts.
Case Report: Here we report a case of osteoblastoma of talus in eighteen year old male patient from Bijapur with complaints of pain and difficulty in walking for one year.