Fully coupled numerical model of actin treadmilling in the lamellipodium of the cell.

Cells rely on an interplay of subcellular elements for motility and migration. Certain regions of motile cells, such as the lamellipodium, are made of a complex mixture of actin monomers and filaments, which polymerize at the front of the cell, close to the cell membrane, and depolymerize at the rear. The dynamic actin turnover induces the so-called intracellular retrograde flow, and it is a fundamental process for cell motility.