Molecular insights into the phase transition of lysozyme into amyloid nanostructures: Implications of therapeutic strategies in diverse pathological conditions.

Lysozyme, a well-known bacteriolytic enzyme, exhibits a fascinating yet complex behavior when it comes to protein aggregation. Under certain conditions, this enzyme undergoes flexible transformation, transitioning from partially unfolded intermediate units of native conformers into complex cross-β-rich nano fibrillar amyloid architectures. Formation of such lysozyme amyloids has been implicated in a multitude of pathological and medical severities, like hepatic dysfunction, hepatomegaly, splenic rupture as well as spleen dysfunction, nephropathy, sicca syndrome, renal dysfunction, renal amyloidosis, and systemic amyloidosis.

Stable 1T-MoS by Facile Phase Transition Synthesis for Efficient Electrocatalytic Oxygen Evolution Reaction.

The 1T phase of MoS exhibits much higher electrocatalytic activity and better stability than the 2H phase. However, the harsh conditions of 1T phase synthesis remain a significant challenge for various extensions and applications of MoS. In this work, a simple hydrothermal-based synthesis method for the phase transition of MoS is being developed.

Bioactivation of an orthodontic wire using multifunctional nanomaterials to prevent plaque accumulation.

Controlling the growth of biofilm on orthodontic material has become a difficult challenge in modern dentistry. The antibacterial efficacy of currently used orthodontic material becomes limited due to the higher affinity of oral microbial flora for plaque formation on the material surface. Thus it is crutial to device an efficient strategy to prevent plaque buildup caused by pathogenic microbiota.

Efficient sonocatalytic degradation of heavy metal and organic pollutants using CuS/MoS nanocomposites.

Eco-friendly and highly effective catalysts are receiving considerable attention for the removal of heavy-metal ions and organic pollutants. In this study, we developed CuS/MoS nanocomposite sonocatalysts to enhance the degradation rate of environmental contaminants by harnessing ultrasonic irradiation. The successful synthesis of nanocomposite sonocatalysts was confirmed by X-ray diffraction (XRD) analysis, and energy-dispersive X-ray spectroscopy.

Mimosine functionalized gold nanoparticles (Mimo-AuNPs) suppress β-amyloid aggregation and neuronal toxicity.

Evidence suggests that increased level/aggregation of beta-amyloid (Aβ) peptides initiate neurodegeneration and subsequent development of Alzheimer's disease (AD). At present, there is no effective treatment for AD. In this study, we reported the effects of gold nanoparticles surface-functionalized with a plant-based amino acid mimosine (Mimo-AuNPs), which is found to cross the blood-brain barrier, on the Aβ fibrillization process and toxicity.