Application of Machine Learning in Rheumatoid Arthritis Diseases Research: Review and Future Directions.

Rheumatoid arthritis (RA) is a chronic, destructive condition that affects and destroys the joints of the hand, fingers, and legs. Patients may forfeit the ability to conduct a normal lifestyle if neglected. The requirement for implementing data science to improve medical care and disease monitoring is emerging rapidly as a consequence of advancements in computational technologies.

Quantification of Lumefantrine in Human Plasma Using LC-MS/MS and Its Application to a Bioequivalence Study.

An analytical method based on protein precipitation has been developed and validated for analysis of lumefantrine in human plasma. Artesunate was used as an internal standard for lumefantrine. Inertsil ODS column provided chromatographic separation of analytes followed by detection with mass spectrometry.

Validated LC-MS/MS method for quantification of agomelatine in human plasma and its application in a pharmacokinetic study.

An analytical method based on liquid-liquid extraction has been developed and validated for analysis of agomelatine in human plasma. Fluoxetine was used as an internal standard for agomelatine. A Betasil C18 (4.